Human antibodies to SARS-CoV-2 with a recurring YYDRxG motif retain binding and neutralization to variants of concern including Omicron

Studying the antibody response to SARS-CoV-2 informs on how the human immune system can respond to antigenic variants as well as other SARS-related viruses. Here, we structurally identified a YYDRxG motif encoded by IGHD3-22 in CDR H3 that facilitates antibody targeting to a functionally conserved e...

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Detalles Bibliográficos
Autores principales: Liu, Hejun, Kaku, Chengzi I., Song, Ge, Yuan, Meng, Andrabi, Raiees, Burton, Dennis R., Walker, Laura M., Wilson, Ian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9336126/
https://www.ncbi.nlm.nih.gov/pubmed/35906394
http://dx.doi.org/10.1038/s42003-022-03700-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9336126/
https://www.ncbi.nlm.nih.gov/pubmed/35906394
http://dx.doi.org/10.1038/s42003-022-03700-6

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