COVID-19 vaccination and BA.1 breakthrough infection induce neutralising antibodies which are less efficient against BA.4 and BA.5 Omicron variants, Israel, March to June 2022

This work evaluated neutralising antibody titres against wild type (WT) SARS-CoV-2 and four Omicron variants (BA.1, BA.2, BA.4 and BA.5) in healthcare workers who had breakthrough BA.1 infection. Omicron breakthrough infection in individuals vaccinated three or four times before infection resulted i...

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Autores principales: Kliker, Limor, Zuckerman, Neta, Atari, Nofar, Barda, Noam, Gilboa, Mayan, Nemet, Ital, Abd Elkader, Bayan, Fratty, Ilana S, Jaber, Hanaa, Mendelson, Ella, Alroy-Preis, Sharon, Kreiss, Yitshak, Regev-Yochay, Gili, Mandelboim, Michal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2022
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9336169/
https://www.ncbi.nlm.nih.gov/pubmed/35904058
http://dx.doi.org/10.2807/1560-7917.ES.2022.27.30.2200559
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author Kliker, Limor
Zuckerman, Neta
Atari, Nofar
Barda, Noam
Gilboa, Mayan
Nemet, Ital
Abd Elkader, Bayan
Fratty, Ilana S
Jaber, Hanaa
Mendelson, Ella
Alroy-Preis, Sharon
Kreiss, Yitshak
Regev-Yochay, Gili
Mandelboim, Michal
author_facet Kliker, Limor
Zuckerman, Neta
Atari, Nofar
Barda, Noam
Gilboa, Mayan
Nemet, Ital
Abd Elkader, Bayan
Fratty, Ilana S
Jaber, Hanaa
Mendelson, Ella
Alroy-Preis, Sharon
Kreiss, Yitshak
Regev-Yochay, Gili
Mandelboim, Michal
author_sort Kliker, Limor
collection PubMed
description This work evaluated neutralising antibody titres against wild type (WT) SARS-CoV-2 and four Omicron variants (BA.1, BA.2, BA.4 and BA.5) in healthcare workers who had breakthrough BA.1 infection. Omicron breakthrough infection in individuals vaccinated three or four times before infection resulted in increased neutralising antibodies against the WT virus. The fourth vaccine dose did not further improve the neutralising efficiency over the third dose against all Omicron variants, especially BA.4 and BA.5. An Omicron-specific vaccine may be indicated.
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spelling pubmed-93361692022-08-10 COVID-19 vaccination and BA.1 breakthrough infection induce neutralising antibodies which are less efficient against BA.4 and BA.5 Omicron variants, Israel, March to June 2022 Kliker, Limor Zuckerman, Neta Atari, Nofar Barda, Noam Gilboa, Mayan Nemet, Ital Abd Elkader, Bayan Fratty, Ilana S Jaber, Hanaa Mendelson, Ella Alroy-Preis, Sharon Kreiss, Yitshak Regev-Yochay, Gili Mandelboim, Michal Euro Surveill Rapid Communication This work evaluated neutralising antibody titres against wild type (WT) SARS-CoV-2 and four Omicron variants (BA.1, BA.2, BA.4 and BA.5) in healthcare workers who had breakthrough BA.1 infection. Omicron breakthrough infection in individuals vaccinated three or four times before infection resulted in increased neutralising antibodies against the WT virus. The fourth vaccine dose did not further improve the neutralising efficiency over the third dose against all Omicron variants, especially BA.4 and BA.5. An Omicron-specific vaccine may be indicated. European Centre for Disease Prevention and Control (ECDC) 2022-07-28 /pmc/articles/PMC9336169/ /pubmed/35904058 http://dx.doi.org/10.2807/1560-7917.ES.2022.27.30.2200559 Text en This article is copyright of the authors or their affiliated institutions, 2022. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Rapid Communication
Kliker, Limor
Zuckerman, Neta
Atari, Nofar
Barda, Noam
Gilboa, Mayan
Nemet, Ital
Abd Elkader, Bayan
Fratty, Ilana S
Jaber, Hanaa
Mendelson, Ella
Alroy-Preis, Sharon
Kreiss, Yitshak
Regev-Yochay, Gili
Mandelboim, Michal
COVID-19 vaccination and BA.1 breakthrough infection induce neutralising antibodies which are less efficient against BA.4 and BA.5 Omicron variants, Israel, March to June 2022
title COVID-19 vaccination and BA.1 breakthrough infection induce neutralising antibodies which are less efficient against BA.4 and BA.5 Omicron variants, Israel, March to June 2022
title_full COVID-19 vaccination and BA.1 breakthrough infection induce neutralising antibodies which are less efficient against BA.4 and BA.5 Omicron variants, Israel, March to June 2022
title_fullStr COVID-19 vaccination and BA.1 breakthrough infection induce neutralising antibodies which are less efficient against BA.4 and BA.5 Omicron variants, Israel, March to June 2022
title_full_unstemmed COVID-19 vaccination and BA.1 breakthrough infection induce neutralising antibodies which are less efficient against BA.4 and BA.5 Omicron variants, Israel, March to June 2022
title_short COVID-19 vaccination and BA.1 breakthrough infection induce neutralising antibodies which are less efficient against BA.4 and BA.5 Omicron variants, Israel, March to June 2022
title_sort covid-19 vaccination and ba.1 breakthrough infection induce neutralising antibodies which are less efficient against ba.4 and ba.5 omicron variants, israel, march to june 2022
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9336169/
https://www.ncbi.nlm.nih.gov/pubmed/35904058
http://dx.doi.org/10.2807/1560-7917.ES.2022.27.30.2200559
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