Associations of a polygenic risk score with coronary artery disease phenotypes in the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial

A polygenic risk score (PGS) is associated with obstructive coronary artery disease (CAD) independent of traditional risk factors. Coronary computed tomography angiography (CTA) can characterize coronary plaques, including features of highrisk CAD. However, it is unknown if a PGS is associated with...

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Autores principales: Newman, Jonathan D., Douglas, Pamela S., Zhbannikov, Ilya, Ferencik, Maros, Foldyna, Borek, Hoffmann, Udo, Shah, Svati H., Ginsburg, Geoffrey S., Lu, Michael T., Voora, Deepak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2022
Materias:
Research Letters
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9336199/
https://www.ncbi.nlm.nih.gov/pubmed/35605652
http://dx.doi.org/10.1016/j.ahj.2022.05.012
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author Newman, Jonathan D.
Douglas, Pamela S.
Zhbannikov, Ilya
Ferencik, Maros
Foldyna, Borek
Hoffmann, Udo
Shah, Svati H.
Ginsburg, Geoffrey S.
Lu, Michael T.
Voora, Deepak
author_facet Newman, Jonathan D.
Douglas, Pamela S.
Zhbannikov, Ilya
Ferencik, Maros
Foldyna, Borek
Hoffmann, Udo
Shah, Svati H.
Ginsburg, Geoffrey S.
Lu, Michael T.
Voora, Deepak
author_sort Newman, Jonathan D.
collection PubMed
description A polygenic risk score (PGS) is associated with obstructive coronary artery disease (CAD) independent of traditional risk factors. Coronary computed tomography angiography (CTA) can characterize coronary plaques, including features of highrisk CAD. However, it is unknown if a PGS is associated with obstructive CAD and high-risk CAD phenotypes in patients with symptoms suggestive of CAD.
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spelling pubmed-93361992022-08-01 Associations of a polygenic risk score with coronary artery disease phenotypes in the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial Newman, Jonathan D. Douglas, Pamela S. Zhbannikov, Ilya Ferencik, Maros Foldyna, Borek Hoffmann, Udo Shah, Svati H. Ginsburg, Geoffrey S. Lu, Michael T. Voora, Deepak Am Heart J Research Letters A polygenic risk score (PGS) is associated with obstructive coronary artery disease (CAD) independent of traditional risk factors. Coronary computed tomography angiography (CTA) can characterize coronary plaques, including features of highrisk CAD. However, it is unknown if a PGS is associated with obstructive CAD and high-risk CAD phenotypes in patients with symptoms suggestive of CAD. Elsevier Inc. 2022-10 2022-05-21 /pmc/articles/PMC9336199/ /pubmed/35605652 http://dx.doi.org/10.1016/j.ahj.2022.05.012 Text en © 2022 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Research Letters
Newman, Jonathan D.
Douglas, Pamela S.
Zhbannikov, Ilya
Ferencik, Maros
Foldyna, Borek
Hoffmann, Udo
Shah, Svati H.
Ginsburg, Geoffrey S.
Lu, Michael T.
Voora, Deepak
Associations of a polygenic risk score with coronary artery disease phenotypes in the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial
title Associations of a polygenic risk score with coronary artery disease phenotypes in the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial
title_full Associations of a polygenic risk score with coronary artery disease phenotypes in the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial
title_fullStr Associations of a polygenic risk score with coronary artery disease phenotypes in the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial
title_full_unstemmed Associations of a polygenic risk score with coronary artery disease phenotypes in the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial
title_short Associations of a polygenic risk score with coronary artery disease phenotypes in the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial
title_sort associations of a polygenic risk score with coronary artery disease phenotypes in the prospective multicenter imaging study for evaluation of chest pain (promise) trial
topic Research Letters
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9336199/
https://www.ncbi.nlm.nih.gov/pubmed/35605652
http://dx.doi.org/10.1016/j.ahj.2022.05.012
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