Chromatin and transcriptomic profiling uncover dysregulation of the Tip60 HAT/HDAC2 epigenomic landscape in the neurodegenerative brain

Disruption of histone acetylation-mediated gene control is a critical step in Alzheimer’s Disease (AD), yet chromatin analysis of antagonistic histone acetyltransferases (HATs) and histone deacetylases (HDACs) causing these alterations remains uncharacterized. We report the first Tip60 HAT versus HD...

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Detalles Bibliográficos
Autores principales: Beaver, Mariah, Karisetty, Bhanu Chandra, Zhang, Haolin, Bhatnagar, Akanksha, Armour, Ellen, Parmar, Visha, Brown, Reshma, Xiang, Merry, Elefant, Felice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9336495/
https://www.ncbi.nlm.nih.gov/pubmed/34369292
http://dx.doi.org/10.1080/15592294.2021.1959742

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9336495/
https://www.ncbi.nlm.nih.gov/pubmed/34369292
http://dx.doi.org/10.1080/15592294.2021.1959742

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