Effects of carbonyl iron powder on iron deficiency anemia and its subchronic toxicity

Carbonyl iron powder (CIP) has been used as a food additive or mineral supplement. However, the effects of CIP on iron deficiency anemia (IDA) and its subchronic toxicity have not been investigated. We found that oral administration of CIP at a dose of 2.96 mg/kg recovered the hemoglobin concentrati...

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Detalles Bibliográficos
Autores principales: Zhu, Qiaosha, Qian, Yang, Yang, Ying, Wu, Weifeng, Xie, Jingli, Wei, Dongzhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taiwan Food and Drug Administration 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9337281/
https://www.ncbi.nlm.nih.gov/pubmed/28911612
http://dx.doi.org/10.1016/j.jfda.2016.04.003
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author Zhu, Qiaosha
Qian, Yang
Yang, Ying
Wu, Weifeng
Xie, Jingli
Wei, Dongzhi
author_facet Zhu, Qiaosha
Qian, Yang
Yang, Ying
Wu, Weifeng
Xie, Jingli
Wei, Dongzhi
author_sort Zhu, Qiaosha
collection PubMed
description Carbonyl iron powder (CIP) has been used as a food additive or mineral supplement. However, the effects of CIP on iron deficiency anemia (IDA) and its subchronic toxicity have not been investigated. We found that oral administration of CIP at a dose of 2.96 mg/kg recovered the hemoglobin concentration of erythrocytes of IDA rats to the normal level after 8 days. The no observed adverse effect level of CIP in rats was considered to be > 200 mg/kg. The hematological and serum biochemical parameters of the rats did not differ significantly between the control and treated groups. There were no morphological changes observed in the organs including liver, kidneys, spleen, testes, stomach and intestine. Therefore, CIP might be a safe iron supplement.
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spelling pubmed-93372812022-08-09 Effects of carbonyl iron powder on iron deficiency anemia and its subchronic toxicity Zhu, Qiaosha Qian, Yang Yang, Ying Wu, Weifeng Xie, Jingli Wei, Dongzhi J Food Drug Anal Original Article Carbonyl iron powder (CIP) has been used as a food additive or mineral supplement. However, the effects of CIP on iron deficiency anemia (IDA) and its subchronic toxicity have not been investigated. We found that oral administration of CIP at a dose of 2.96 mg/kg recovered the hemoglobin concentration of erythrocytes of IDA rats to the normal level after 8 days. The no observed adverse effect level of CIP in rats was considered to be > 200 mg/kg. The hematological and serum biochemical parameters of the rats did not differ significantly between the control and treated groups. There were no morphological changes observed in the organs including liver, kidneys, spleen, testes, stomach and intestine. Therefore, CIP might be a safe iron supplement. Taiwan Food and Drug Administration 2016-06-02 /pmc/articles/PMC9337281/ /pubmed/28911612 http://dx.doi.org/10.1016/j.jfda.2016.04.003 Text en © 2016 Taiwan Food and Drug Administration https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ).
spellingShingle Original Article
Zhu, Qiaosha
Qian, Yang
Yang, Ying
Wu, Weifeng
Xie, Jingli
Wei, Dongzhi
Effects of carbonyl iron powder on iron deficiency anemia and its subchronic toxicity
title Effects of carbonyl iron powder on iron deficiency anemia and its subchronic toxicity
title_full Effects of carbonyl iron powder on iron deficiency anemia and its subchronic toxicity
title_fullStr Effects of carbonyl iron powder on iron deficiency anemia and its subchronic toxicity
title_full_unstemmed Effects of carbonyl iron powder on iron deficiency anemia and its subchronic toxicity
title_short Effects of carbonyl iron powder on iron deficiency anemia and its subchronic toxicity
title_sort effects of carbonyl iron powder on iron deficiency anemia and its subchronic toxicity
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9337281/
https://www.ncbi.nlm.nih.gov/pubmed/28911612
http://dx.doi.org/10.1016/j.jfda.2016.04.003
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