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Placental vascular remodeling in pregnant women with COVID-19

Severe acute respiratory syndrome coronavirus 2 has been causing the pandemic of coronavirus disease 2019 (COVID-19) that has so far resulted in over 450 million infections and six million deaths. This respiratory virus uses angiotensin-converting enzyme 2 as a receptor to enter host cells and affec...

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Autores principales: Gychka, Sergiy G., Brelidze, Tinatin I., Kuchyn, Iurii L., Savchuk, Tetyana V., Nikolaienko, Sofia I., Zhezhera, Volodymyr M., Chermak, Ihor I., Suzuki, Yuichiro J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9337689/
https://www.ncbi.nlm.nih.gov/pubmed/35905056
http://dx.doi.org/10.1371/journal.pone.0268591
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author Gychka, Sergiy G.
Brelidze, Tinatin I.
Kuchyn, Iurii L.
Savchuk, Tetyana V.
Nikolaienko, Sofia I.
Zhezhera, Volodymyr M.
Chermak, Ihor I.
Suzuki, Yuichiro J.
author_facet Gychka, Sergiy G.
Brelidze, Tinatin I.
Kuchyn, Iurii L.
Savchuk, Tetyana V.
Nikolaienko, Sofia I.
Zhezhera, Volodymyr M.
Chermak, Ihor I.
Suzuki, Yuichiro J.
author_sort Gychka, Sergiy G.
collection PubMed
description Severe acute respiratory syndrome coronavirus 2 has been causing the pandemic of coronavirus disease 2019 (COVID-19) that has so far resulted in over 450 million infections and six million deaths. This respiratory virus uses angiotensin-converting enzyme 2 as a receptor to enter host cells and affects various tissues in addition to the lungs. The present study reports that the placental arteries of women who gave birth to live full-term newborns while developing COVID-19 during pregnancy exhibit severe vascular wall thickening and the occlusion of the vascular lumen. A morphometric analysis of the placental arteries stained with hematoxylin and eosin suggests a 2-fold increase in wall thickness and a 5-fold decrease in the lumen area. Placental vascular remodeling was found to occur in all of SARS-CoV-2-positive mothers as defined by RT-PCR. Immunohistochemistry with α-smooth muscle actin and the Kv11.1 channel as well as Masson’s trichrome staining showed that such placental vascular remodeling in COVID-19 is associated with smooth muscle proliferation and fibrosis. Placental vascular remodeling may represent a response mechanism to the clinical problems associated with childbirth in COVID-19 patients.
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spelling pubmed-93376892022-07-30 Placental vascular remodeling in pregnant women with COVID-19 Gychka, Sergiy G. Brelidze, Tinatin I. Kuchyn, Iurii L. Savchuk, Tetyana V. Nikolaienko, Sofia I. Zhezhera, Volodymyr M. Chermak, Ihor I. Suzuki, Yuichiro J. PLoS One Research Article Severe acute respiratory syndrome coronavirus 2 has been causing the pandemic of coronavirus disease 2019 (COVID-19) that has so far resulted in over 450 million infections and six million deaths. This respiratory virus uses angiotensin-converting enzyme 2 as a receptor to enter host cells and affects various tissues in addition to the lungs. The present study reports that the placental arteries of women who gave birth to live full-term newborns while developing COVID-19 during pregnancy exhibit severe vascular wall thickening and the occlusion of the vascular lumen. A morphometric analysis of the placental arteries stained with hematoxylin and eosin suggests a 2-fold increase in wall thickness and a 5-fold decrease in the lumen area. Placental vascular remodeling was found to occur in all of SARS-CoV-2-positive mothers as defined by RT-PCR. Immunohistochemistry with α-smooth muscle actin and the Kv11.1 channel as well as Masson’s trichrome staining showed that such placental vascular remodeling in COVID-19 is associated with smooth muscle proliferation and fibrosis. Placental vascular remodeling may represent a response mechanism to the clinical problems associated with childbirth in COVID-19 patients. Public Library of Science 2022-07-29 /pmc/articles/PMC9337689/ /pubmed/35905056 http://dx.doi.org/10.1371/journal.pone.0268591 Text en © 2022 Gychka et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Gychka, Sergiy G.
Brelidze, Tinatin I.
Kuchyn, Iurii L.
Savchuk, Tetyana V.
Nikolaienko, Sofia I.
Zhezhera, Volodymyr M.
Chermak, Ihor I.
Suzuki, Yuichiro J.
Placental vascular remodeling in pregnant women with COVID-19
title Placental vascular remodeling in pregnant women with COVID-19
title_full Placental vascular remodeling in pregnant women with COVID-19
title_fullStr Placental vascular remodeling in pregnant women with COVID-19
title_full_unstemmed Placental vascular remodeling in pregnant women with COVID-19
title_short Placental vascular remodeling in pregnant women with COVID-19
title_sort placental vascular remodeling in pregnant women with covid-19
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9337689/
https://www.ncbi.nlm.nih.gov/pubmed/35905056
http://dx.doi.org/10.1371/journal.pone.0268591
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