Evidence for a neuromuscular circuit involving hypothalamic interleukin-6 in the control of skeletal muscle metabolism

Hypothalamic interleukin-6 (IL6) exerts a broad metabolic control. Here, we demonstrated that IL6 activates the ERK1/2 pathway in the ventromedial hypothalamus (VMH), stimulating AMPK/ACC signaling and fatty acid oxidation in mouse skeletal muscle. Bioinformatics analysis revealed that the hypothala...

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Detalles Bibliográficos
Autores principales: Katashima, Carlos Kiyoshi, de Oliveira Micheletti, Thayana, Braga, Renata Rosseto, Gaspar, Rodrigo Stellzer, Goeminne, Ludger J. E., Moura-Assis, Alexandre, Crisol, Barbara Moreira, Brícola, Rafael S., Silva, Vagner Ramon R., de Oliveira Ramos, Camila, da Rocha, Alisson L., Tavares, Mariana Rosolen, Simabuco, Fernando Moreira, Matheus, Valquiria Aparecida, Buscaratti, Lucas, Marques-Souza, Henrique, Pazos, Patricia, Gonzalez-Touceda, David, Tovar, Sulay, del Carmen García, María, Neto, Jose Cesar Rosa, Curi, Rui, Hirabara, Sandro Massao, Brum, Patrícia Chakur, Prada, Patrícia Oliveira, de Moura, Leandro P., Pauli, José Rodrigo, da Silva, Adelino S. R., Cintra, Dennys Esper, Velloso, Licio A., Ropelle, Eduardo Rochete
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9337767/
https://www.ncbi.nlm.nih.gov/pubmed/35905178
http://dx.doi.org/10.1126/sciadv.abm7355

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