Cargando…

Shared brain transcriptomic signature in TDP-43 type A FTLD patients with or without GRN mutations

Frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) is a complex heterogeneous neurodegenerative disorder for which mechanisms are poorly understood. To explore transcriptional changes underlying FTLD-TDP, we performed RNA-sequencing on 66 genetically unexplained FTLD-TDP patients, 2...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pottier, Cyril, Mateiu, Ligia, Baker, Matthew C, DeJesus-Hernandez, Mariely, Teixeira Vicente, Cristina, Finch, NiCole A, Tian, Shulan, van Blitterswijk, Marka, Murray, Melissa E, Ren, Yingxue, Petrucelli, Leonard, Oskarsson, Björn, Biernacka, Joanna M, Graff-Radford, Neill R, Boeve, Bradley F, Petersen, Ronald C, Josephs, Keith A, Asmann, Yan W, Dickson, Dennis W, Rademakers, Rosa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9337811/ https://www.ncbi.nlm.nih.gov/pubmed/34918030 http://dx.doi.org/10.1093/brain/awab437

Ejemplares similares

Evidence of cerebellar TDP-43 loss of function in FTLD-TDP
por: Pickles, Sarah, et al.
Publicado: (2022)

C-terminal and full length TDP-43 specie differ according to FTLD-TDP lesion type but not genetic mutation
por: Josephs, Keith A., et al.
Publicado: (2019)

Extensive transcriptomic study emphasizes importance of vesicular transport in C9orf72 expansion carriers
por: Dickson, Dennis W., et al.
Publicado: (2019)

Altered microRNA expression in frontotemporal lobar degeneration with TDP-43 pathology caused by progranulin mutations
por: Kocerha, Jannet, et al.
Publicado: (2011)

Investigating the role of filamin C in Belgian patients with frontotemporal dementia linked to GRN deficiency in FTLD-TDP brains
por: Janssens, Jonathan, et al.
Publicado: (2015)

Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia
por: Rademakers, Rosa, et al.
Publicado: (2008)

Glia in FTLD-GRN: from supporting cast to leading role
por: Pinarbasi, Emile S., et al.
Publicado: (2023)

AAV-GRN partially corrects motor deficits and ALS/FTLD-related pathology in Tmem106b(−/−)Grn(−/−) mice
por: Feng, Tuancheng, et al.
Publicado: (2023)

Distinguishing post‐translational modifications in dominantly inherited frontotemporal dementias: FTLD‐TDP Type A (GRN) vs Type B (C9orf72)
por: Cracco, Laura, et al.
Publicado: (2022)

Long-read targeted sequencing uncovers clinicopathological associations for C9orf72-linked diseases
por: DeJesus-Hernandez, Mariely, et al.
Publicado: (2021)

In-depth clinico-pathological examination of RNA foci in a large cohort of C9ORF72 expansion carriers
por: DeJesus-Hernandez, Mariely, et al.
Publicado: (2017)

White matter lesions in FTLD: distinct phenotypes characterize GRN and C9ORF72 mutations
por: Ameur, Fatima, et al.
Publicado: (2016)

Extended FTLD pedigree segregating a Belgian GRN-null mutation: neuropathological heterogeneity in one family
por: Sieben, Anne, et al.
Publicado: (2018)

Towards a TDP-43-Based Biomarker for ALS and FTLD
por: Feneberg, Emily, et al.
Publicado: (2018)

The Pathobiology of TDP-43 C-Terminal Fragments in ALS and FTLD
por: Berning, Britt A., et al.
Publicado: (2019)

Neuronal VCP loss of function recapitulates FTLD-TDP pathology
por: Wani, Abubakar, et al.
Publicado: (2021)

Elevated methylation levels, reduced expression levels, and frequent contractions in a clinical cohort of C9orf72 expansion carriers
por: Jackson, Jazmyne L., et al.
Publicado: (2020)

Microglial lysosome dysfunction contributes to white matter pathology and TDP-43 proteinopathy in GRN-associated FTD
por: Wu, Yanwei, et al.
Publicado: (2021)

Repetitive element transcripts are elevated in the brain of C9orf72 ALS/FTLD patients
por: Prudencio, Mercedes, et al.
Publicado: (2017)

Movement disorders are linked to TDP-43 burden in the substantia nigra of FTLD-TDP brain donors
por: Fiondella, Luigi, et al.
Publicado: (2023)

TDP-43 forms amyloid filaments with a distinct fold in type A FTLD-TDP
por: Arseni, Diana, et al.
Publicado: (2023)

Diffuse argyrophilic grain disease with TDP-43 proteinopathy and neuronal intermediate filament inclusion disease: FTLD with mixed tau, TDP-43 and FUS pathologies
por: Koga, Shunsuke, et al.
Publicado: (2023)

Therapeutic effect of berberine on TDP-43-related pathogenesis in FTLD and ALS
por: Chang, Cheng-Fu, et al.
Publicado: (2016)

Molecular Dissection of TDP-43 as a Leading Cause of ALS/FTLD
por: Tamaki, Yoshitaka, et al.
Publicado: (2022)

Patients with sporadic FTLD exhibit similar increases in lysosomal proteins and storage material as patients with FTD due to GRN mutations
por: Davis, Skylar E., et al.
Publicado: (2023)

Novel GRN mutation presenting as an aphasic dementia and evolving into corticobasal syndrome
por: Botha, Hugo, et al.
Publicado: (2017)

Publisher Correction to: Diffuse argyrophilic grain disease with TDP-43 proteinopathy and neuronal intermediate filament inclusion disease: FTLD with mixed tau, TDP-43 and FUS pathologies
por: Koga, Shunsuke, et al.
Publicado: (2023)

Abnormal expression of homeobox genes and transthyretin in C9ORF72 expansion carriers
por: Finch, NiCole A., et al.
Publicado: (2017)

Antibody against TDP-43 phosphorylated at serine 375 suggests conformational differences of TDP-43 aggregates among FTLD–TDP subtypes
por: Neumann, Manuela, et al.
Publicado: (2020)

Classification of FTLD-TDP cases into pathological subtypes using antibodies against phosphorylated and non-phosphorylated TDP43
por: Tan, Rachel H, et al.
Publicado: (2013)

Old age amyotrophic lateral sclerosis and limbic TDP‐43 pathology
por: Murakami, Aya, et al.
Publicado: (2022)

TDP-43-regulated cryptic RNAs accumulate in Alzheimer’s disease brains
por: Estades Ayuso, Virginia, et al.
Publicado: (2023)

Regional and hemispheric susceptibility of the temporal lobe to FTLD-TDP type C pathology
por: Borghesani, V., et al.
Publicado: (2020)

Pathological mechanisms underlying TDP-43 driven neurodegeneration in FTLD–ALS spectrum disorders
por: Janssens, Jonathan, et al.
Publicado: (2013)

Molecular Mechanisms Underlying TDP-43 Pathology in Cellular and Animal Models of ALS and FTLD
por: Wood, Alistair, et al.
Publicado: (2021)

NUP62 localizes to ALS/FTLD pathological assemblies and contributes to TDP-43 insolubility
por: Gleixner, Amanda M., et al.
Publicado: (2022)

Codon-optimized TDP-43 mediates neurodegeneration in a Drosophila model of ALS/FTLD
por: Yusuff, Tanzeen, et al.
Publicado: (2023)

TDP-43 Vasculopathy in the Spinal Cord in Sporadic Amyotrophic Lateral Sclerosis (sALS) and Frontal Cortex in sALS/FTLD-TDP
por: Ferrer, Isidro, et al.
Publicado: (2021)

Teaching case 3-2019: Are nuclear clefts or invaginations the niche of intranuclear inclusions in FTLD-TDP?
por: Molina-Porcel, Laura, et al.
Publicado: (2019)

Microglia in frontotemporal lobar degeneration with progranulin or C9ORF72 mutations
por: Sakae, Nobutaka, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_ju52qfu2la384f6lqj6r6t8c6f