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Shared brain transcriptomic signature in TDP-43 type A FTLD patients with or without GRN mutations

Frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) is a complex heterogeneous neurodegenerative disorder for which mechanisms are poorly understood. To explore transcriptional changes underlying FTLD-TDP, we performed RNA-sequencing on 66 genetically unexplained FTLD-TDP patients, 2...

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Detalles Bibliográficos
Autores principales:	Pottier, Cyril, Mateiu, Ligia, Baker, Matthew C, DeJesus-Hernandez, Mariely, Teixeira Vicente, Cristina, Finch, NiCole A, Tian, Shulan, van Blitterswijk, Marka, Murray, Melissa E, Ren, Yingxue, Petrucelli, Leonard, Oskarsson, Björn, Biernacka, Joanna M, Graff-Radford, Neill R, Boeve, Bradley F, Petersen, Ronald C, Josephs, Keith A, Asmann, Yan W, Dickson, Dennis W, Rademakers, Rosa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9337811/ https://www.ncbi.nlm.nih.gov/pubmed/34918030 http://dx.doi.org/10.1093/brain/awab437

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