AMPK-mediated potentiation of GABAergic signalling drives hypoglycaemia-provoked spike-wave seizures

Metabolism regulates neuronal activity and modulates the occurrence of epileptic seizures. Here, using two rodent models of absence epilepsy, we show that hypoglycaemia increases the occurrence of spike-wave seizures. We then show that selectively disrupting glycolysis in the thalamus, a structure i...

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Detalles Bibliográficos
Autores principales: Salvati, Kathryn A, Ritger, Matthew L, Davoudian, Pasha A, O’Dell, Finnegan, Wyskiel, Daniel R, Souza, George M P R, Lu, Adam C, Perez-Reyes, Edward, Drake, Joshua C, Yan, Zhen, Beenhakker, Mark P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9337815/
https://www.ncbi.nlm.nih.gov/pubmed/35134125
http://dx.doi.org/10.1093/brain/awac037

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