mTORC2 mediates structural plasticity in distal nociceptive endings that contributes to pain hypersensitivity following inflammation

The encoding of noxious stimuli into action potential firing is largely mediated by nociceptive free nerve endings. Tissue inflammation, by changing the intrinsic properties of the nociceptive endings, leads to nociceptive hyperexcitability and thus to the development of inflammatory pain. Here, we...

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Detalles Bibliográficos
Autores principales: Wong, Calvin, Barkai, Omer, Wang, Feng, Perez, Carolina Thörn, Lev, Shaya, Cai, Weihua, Tansley, Shannon, Yousefpour, Noosha, Hooshmandi, Mehdi, Lister, Kevin C., Latif, Mariam, Cuello, A. Claudio, Prager-Khoutorsky, Masha, Mogil, Jeffrey S., Séguéla, Philippe, De Koninck, Yves, Ribeiro-da-Silva, Alfredo, Binshtok, Alexander M., Khoutorsky, Arkady
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9337825/
https://www.ncbi.nlm.nih.gov/pubmed/35579957
http://dx.doi.org/10.1172/JCI152635

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