Lymphangiogenesis requires Ang2/Tie/PI3K signaling for VEGFR3 cell-surface expression

Vascular endothelial growth factor C (VEGF-C) induces lymphangiogenesis via VEGF receptor 3 (VEGFR3), which is encoded by the most frequently mutated gene in human primary lymphedema. Angiopoietins (Angs) and their Tie receptors regulate lymphatic vessel development, and mutations of the ANGPT2 gene...

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Detalles Bibliográficos
Autores principales: Korhonen, Emilia A., Murtomäki, Aino, Jha, Sawan Kumar, Anisimov, Andrey, Pink, Anne, Zhang, Yan, Stritt, Simon, Liaqat, Inam, Stanczuk, Lukas, Alderfer, Laura, Sun, Zhiliang, Kapiainen, Emmi, Singh, Abhishek, Sultan, Ibrahim, Lantta, Anni, Leppänen, Veli-Matti, Eklund, Lauri, He, Yulong, Augustin, Hellmut G., Vaahtomeri, Kari, Saharinen, Pipsa, Mäkinen, Taija, Alitalo, Kari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9337826/
https://www.ncbi.nlm.nih.gov/pubmed/35763346
http://dx.doi.org/10.1172/JCI155478

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