Disrupting the DREAM complex enables proliferation of adult human pancreatic β cells

Resistance to regeneration of insulin-producing pancreatic β cells is a fundamental challenge for type 1 and type 2 diabetes. Recently, small molecule inhibitors of the kinase DYRK1A have proven effective in inducing adult human β cells to proliferate, but their detailed mechanism of action is incom...

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Detalles Bibliográficos
Autores principales: Wang, Peng, Karakose, Esra, Argmann, Carmen, Wang, Huan, Balev, Metodi, Brody, Rachel I., Rivas, Hembly G., Liu, Xinyue, Wood, Olivia, Liu, Hongtao, Choleva, Lauryn, Hasson, Dan, Bernstein, Emily, Paulo, Joao A., Scott, Donald K., Lambertini, Luca, DeCaprio, James A., Stewart, Andrew F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9337832/
https://www.ncbi.nlm.nih.gov/pubmed/35700053
http://dx.doi.org/10.1172/JCI157086

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