Research Progress Based on Regulation of Tumor Microenvironment Redox and Drug-Loaded Metal-Organic Frameworks

The process of tumor growth and deterioration is accompanied by increased oxygen free radicals, high glutathione concentration, hypoxia, and poor drug targeting during treatment, limiting the treatment of tumors. Metal-organic framework (MOF) preparations are continuously being developed and applied...

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Detalles Bibliográficos
Autor principal: Xu, Tong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9337949/
https://www.ncbi.nlm.nih.gov/pubmed/35910842
http://dx.doi.org/10.1155/2022/7302883
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author Xu, Tong
author_facet Xu, Tong
author_sort Xu, Tong
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description The process of tumor growth and deterioration is accompanied by increased oxygen free radicals, high glutathione concentration, hypoxia, and poor drug targeting during treatment, limiting the treatment of tumors. Metal-organic framework (MOF) preparations are continuously being developed and applied in tumor therapy. In this paper, the design and application of reactive oxygen species (ROS) and redox drug-loaded MOF preparations are reviewed. Moreover, the research challenges and application prospects of MOFs in tumor therapy are also discussed.
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spelling pubmed-93379492022-07-30 Research Progress Based on Regulation of Tumor Microenvironment Redox and Drug-Loaded Metal-Organic Frameworks Xu, Tong Oxid Med Cell Longev Review Article The process of tumor growth and deterioration is accompanied by increased oxygen free radicals, high glutathione concentration, hypoxia, and poor drug targeting during treatment, limiting the treatment of tumors. Metal-organic framework (MOF) preparations are continuously being developed and applied in tumor therapy. In this paper, the design and application of reactive oxygen species (ROS) and redox drug-loaded MOF preparations are reviewed. Moreover, the research challenges and application prospects of MOFs in tumor therapy are also discussed. Hindawi 2022-07-22 /pmc/articles/PMC9337949/ /pubmed/35910842 http://dx.doi.org/10.1155/2022/7302883 Text en Copyright © 2022 Tong Xu. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Xu, Tong
Research Progress Based on Regulation of Tumor Microenvironment Redox and Drug-Loaded Metal-Organic Frameworks
title Research Progress Based on Regulation of Tumor Microenvironment Redox and Drug-Loaded Metal-Organic Frameworks
title_full Research Progress Based on Regulation of Tumor Microenvironment Redox and Drug-Loaded Metal-Organic Frameworks
title_fullStr Research Progress Based on Regulation of Tumor Microenvironment Redox and Drug-Loaded Metal-Organic Frameworks
title_full_unstemmed Research Progress Based on Regulation of Tumor Microenvironment Redox and Drug-Loaded Metal-Organic Frameworks
title_short Research Progress Based on Regulation of Tumor Microenvironment Redox and Drug-Loaded Metal-Organic Frameworks
title_sort research progress based on regulation of tumor microenvironment redox and drug-loaded metal-organic frameworks
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9337949/
https://www.ncbi.nlm.nih.gov/pubmed/35910842
http://dx.doi.org/10.1155/2022/7302883
work_keys_str_mv AT xutong researchprogressbasedonregulationoftumormicroenvironmentredoxanddrugloadedmetalorganicframeworks

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