TRIM28-dependent SUMOylation protects the adult ovary from activation of the testicular pathway

Gonadal sexual fate in mammals is determined during embryonic development and must be actively maintained in adulthood. In the mouse ovary, oestrogen receptors and FOXL2 protect ovarian granulosa cells from transdifferentiation into Sertoli cells, their testicular counterpart. However, the mechanism...

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Detalles Bibliográficos
Autores principales: Rossitto, Moïra, Déjardin, Stephanie, Rands, Chris M., Le Gras, Stephanie, Migale, Roberta, Rafiee, Mahmoud-Reza, Neirijnck, Yasmine, Pruvost, Alain, Nguyen, Anvi Laetitia, Bossis, Guillaume, Cammas, Florence, Le Gallic, Lionel, Wilhelm, Dagmar, Lovell-Badge, Robin, Boizet-Bonhoure, Brigitte, Nef, Serge, Poulat, Francis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338040/
https://www.ncbi.nlm.nih.gov/pubmed/35906245
http://dx.doi.org/10.1038/s41467-022-32061-1

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