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Pharmacokinetic Drug–Drug Interaction Studies Between Trilaciclib and Midazolam, Metformin, Rifampin, Itraconazole, and Topotecan in Healthy Volunteers and Patients with Extensive-Stage Small-Cell Lung Cancer

BACKGROUND AND OBJECTIVE: Trilaciclib is a cyclin-dependent kinase 4/6 inhibitor indicated to decrease the incidence of chemotherapy-induced myelosuppression in patients with extensive-stage small-cell lung cancer. Trilaciclib is a substrate and time-dependent inhibitor of cytochrome P450 3A4 and an...

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Detalles Bibliográficos
Autores principales:	Li, Chao, Horton, Janet K., Sale, Mark, Curd, Laura, Goti, Vineet, Tao, Wenli, Beelen, Andrew
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2022
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338108/ https://www.ncbi.nlm.nih.gov/pubmed/35842567 http://dx.doi.org/10.1007/s40261-022-01179-x

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