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Functional characterization of FBXL7 as a novel player in human cancers

F-box and leucine-rich repeat protein 7 (FBXL7), an F-box protein responsible for substrate recognition by the SKP1-Cullin-1-F-box (SCF) ubiquitin ligases, plays an emerging role in the regulation of tumorigenesis and tumor progression. FBXL7 promotes polyubiquitylation and degradation of diverse su...

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Autores principales: Wang, Yue, Shen, Xiao, Gong, Longyuan, Zhao, Yongchao, Xiong, Xiufang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338262/
https://www.ncbi.nlm.nih.gov/pubmed/35906197
http://dx.doi.org/10.1038/s41420-022-01143-w
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author Wang, Yue
Shen, Xiao
Gong, Longyuan
Zhao, Yongchao
Xiong, Xiufang
author_facet Wang, Yue
Shen, Xiao
Gong, Longyuan
Zhao, Yongchao
Xiong, Xiufang
author_sort Wang, Yue
collection PubMed
description F-box and leucine-rich repeat protein 7 (FBXL7), an F-box protein responsible for substrate recognition by the SKP1-Cullin-1-F-box (SCF) ubiquitin ligases, plays an emerging role in the regulation of tumorigenesis and tumor progression. FBXL7 promotes polyubiquitylation and degradation of diverse substrates and is involved in many biological processes, including apoptosis, cell proliferation, cell migration and invasion, tumor metastasis, DNA damage, glucose metabolism, planar cell polarity, and drug resistance. In this review, we summarize the downstream substrates and upstream regulators of FBXL7. We then discuss its role in tumorigenesis and tumor progression as either an oncoprotein or a tumor suppressor, and further describe its aberrant expression and association with patient survival in human cancers. Finally, we provide future perspectives on validating FBXL7 as a cancer biomarker for diagnosis and prognosis and/or as a potential therapeutic target for anticancer treatment.
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spelling pubmed-93382622022-07-31 Functional characterization of FBXL7 as a novel player in human cancers Wang, Yue Shen, Xiao Gong, Longyuan Zhao, Yongchao Xiong, Xiufang Cell Death Discov Review Article F-box and leucine-rich repeat protein 7 (FBXL7), an F-box protein responsible for substrate recognition by the SKP1-Cullin-1-F-box (SCF) ubiquitin ligases, plays an emerging role in the regulation of tumorigenesis and tumor progression. FBXL7 promotes polyubiquitylation and degradation of diverse substrates and is involved in many biological processes, including apoptosis, cell proliferation, cell migration and invasion, tumor metastasis, DNA damage, glucose metabolism, planar cell polarity, and drug resistance. In this review, we summarize the downstream substrates and upstream regulators of FBXL7. We then discuss its role in tumorigenesis and tumor progression as either an oncoprotein or a tumor suppressor, and further describe its aberrant expression and association with patient survival in human cancers. Finally, we provide future perspectives on validating FBXL7 as a cancer biomarker for diagnosis and prognosis and/or as a potential therapeutic target for anticancer treatment. Nature Publishing Group UK 2022-07-29 /pmc/articles/PMC9338262/ /pubmed/35906197 http://dx.doi.org/10.1038/s41420-022-01143-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Wang, Yue
Shen, Xiao
Gong, Longyuan
Zhao, Yongchao
Xiong, Xiufang
Functional characterization of FBXL7 as a novel player in human cancers
title Functional characterization of FBXL7 as a novel player in human cancers
title_full Functional characterization of FBXL7 as a novel player in human cancers
title_fullStr Functional characterization of FBXL7 as a novel player in human cancers
title_full_unstemmed Functional characterization of FBXL7 as a novel player in human cancers
title_short Functional characterization of FBXL7 as a novel player in human cancers
title_sort functional characterization of fbxl7 as a novel player in human cancers
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338262/
https://www.ncbi.nlm.nih.gov/pubmed/35906197
http://dx.doi.org/10.1038/s41420-022-01143-w
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