Pathogen-selective killing by guanylate-binding proteins as a molecular mechanism leading to inflammasome signaling

Inflammasomes are cytosolic signaling complexes capable of sensing microbial ligands to trigger inflammation and cell death responses. Here, we show that guanylate-binding proteins (GBPs) mediate pathogen-selective inflammasome activation. We show that mouse GBP1 and GBP3 are specifically required f...

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Detalles Bibliográficos
Autores principales: Feng, Shouya, Enosi Tuipulotu, Daniel, Pandey, Abhimanu, Jing, Weidong, Shen, Cheng, Ngo, Chinh, Tessema, Melkamu B., Li, Fei-Ju, Fox, Daniel, Mathur, Anukriti, Zhao, Anyang, Wang, Runli, Pfeffer, Klaus, Degrandi, Daniel, Yamamoto, Masahiro, Reading, Patrick C., Burgio, Gaetan, Man, Si Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338265/
https://www.ncbi.nlm.nih.gov/pubmed/35906252
http://dx.doi.org/10.1038/s41467-022-32127-0

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