Tryptophan C-mannosylation is critical for Plasmodium falciparum transmission

Tryptophan C-mannosylation stabilizes proteins bearing a thrombospondin repeat (TSR) domain in metazoans. Here we show that Plasmodium falciparum expresses a DPY19 tryptophan C-mannosyltransferase in the endoplasmic reticulum and that DPY19-deficiency abolishes C-glycosylation, destabilizes members...

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Detalles Bibliográficos
Autores principales: Lopaticki, Sash, McConville, Robyn, John, Alan, Geoghegan, Niall, Mohamed, Shihab Deen, Verzier, Lisa, Steel, Ryan W. J., Evelyn, Cindy, O’Neill, Matthew T., Soler, Niccolay Madiedo, Scott, Nichollas E., Rogers, Kelly L., Goddard-Borger, Ethan D., Boddey, Justin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338275/
https://www.ncbi.nlm.nih.gov/pubmed/35906227
http://dx.doi.org/10.1038/s41467-022-32076-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338275/
https://www.ncbi.nlm.nih.gov/pubmed/35906227
http://dx.doi.org/10.1038/s41467-022-32076-8

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