CDK9 activity switch associated with AFF1 and HEXIM1 controls differentiation initiation from epidermal progenitors

Progenitors in epithelial tissues, such as human skin epidermis, continuously make fate decisions between self-renewal and differentiation. Here we show that the Super Elongation Complex (SEC) controls progenitor fate decisions by directly suppressing a group of “rapid response” genes, which feature...

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Detalles Bibliográficos
Autores principales: Lloyd, Sarah M., Leon, Daniel B., Brady, Mari O., Rodriguez, Deborah, McReynolds, Madison P., Kweon, Junghun, Neely, Amy E., Blumensaadt, Laura A., Ho, Patric J., Bao, Xiaomin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338292/
https://www.ncbi.nlm.nih.gov/pubmed/35906225
http://dx.doi.org/10.1038/s41467-022-32098-2

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