Extracellular Histones Activate Endothelial NLRP3 Inflammasome and are Associated with a Severe Sepsis Phenotype

INTRODUCTION: Circulating extracellular histones acquire relevance as cytotoxic mediators in sepsis. Extracellular histones act as damage-associated molecular patterns (DAMPs), which induce oxidative stress and NLRP3 inflammasome activation. Inflammasome mediates pyroptosis, a programmed cell death...

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Detalles Bibliográficos
Autores principales: Beltrán-García, Jesús, Osca-Verdegal, Rebeca, Pérez-Cremades, Daniel, Novella, Susana, Hermenegildo, Carlos, Pallardó, Federico V, García-Giménez, José Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338392/
https://www.ncbi.nlm.nih.gov/pubmed/35915852
http://dx.doi.org/10.2147/JIR.S363693

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