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Full-length transcriptomic analysis in murine and human heart reveals diversity of PGC-1α promoters and isoforms regulated distinctly in myocardial ischemia and obesity

BACKGROUND: Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) acts as a transcriptional coactivator and regulates mitochondrial function. Various isoforms are generated by alternative splicing and differentially regulated promoters. In the heart, total PGC-1α deficiency k...

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Detalles Bibliográficos
Autores principales:	Oehler, Daniel, Spychala, André, Gödecke, Axel, Lang, Alexander, Gerdes, Norbert, Ruas, Jorge, Kelm, Malte, Szendroedi, Julia, Westenfeld, Ralf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338484/ https://www.ncbi.nlm.nih.gov/pubmed/35907957 http://dx.doi.org/10.1186/s12915-022-01360-w

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