Oxysterol derivatives Oxy186 and Oxy210 inhibit WNT signaling in non-small cell lung cancer

BACKGROUND: Developmental signaling pathways such as those of Hedgehog (HH) and WNT play critical roles in cancer stem cell self-renewal, migration, and differentiation. They are often constitutively activated in many human malignancies, including non-small cell lung cancer (NSCLC). Previously, we r...

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Detalles Bibliográficos
Autores principales: Tang, Liu-Ya, Spezia, Marie, Chen, Ting, Shin, Jee-Hye, Wang, Feng, Stappenbeck, Frank, Lebensohn, Andres M., Parhami, Farhad, Zhang, Ying E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338492/
https://www.ncbi.nlm.nih.gov/pubmed/35908024
http://dx.doi.org/10.1186/s13578-022-00857-9

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