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Rational design of AAVrh10-vectored ACE2 functional domain to broadly block the cell entry of SARS-CoV-2 variants

The frequently emerging SARS-CoV-2 variants have weakened the effectiveness of existing COVID-19 vaccines and neutralizing antibody therapy. Nevertheless, the infections of SARS-CoV-2 variants still depend on angiotensin-converting enzyme 2 (ACE2) receptor-mediated cell entry, and thus the soluble h...

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Detalles Bibliográficos
Autores principales:	Li, Minchao, Chen, Jiaoshan, Liu, Yajie, Zhao, Jin, Li, Yanjun, Hu, Yunqi, Chen, Yao-qing, Sun, Litao, Shu, Yuelong, Feng, Fengling, Sun, Caijun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier B.V. 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338828/ https://www.ncbi.nlm.nih.gov/pubmed/35917969 http://dx.doi.org/10.1016/j.antiviral.2022.105383

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