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Assessment of Early Response to Lung Cancer Chemotherapy by Semiquantitative Analysis of Dynamic Contrast-Enhanced MRI

OBJECTIVE: To evaluate the early chemotherapy response in patients with lung cancer using semiquantitative analysis of dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI). METHODS: Twenty-two patients with lung cancer treated with chemotherapy were subjected to DCE-MRI at two time point...

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Autores principales: Zhu, Jiang, Yun, Jian, Wang, Kaixiang, Liu, Liangqing, Zheng, Jiangang, Mei, Li, Xu, Jianxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338849/
https://www.ncbi.nlm.nih.gov/pubmed/35915736
http://dx.doi.org/10.1155/2022/2669281
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author Zhu, Jiang
Yun, Jian
Wang, Kaixiang
Liu, Liangqing
Zheng, Jiangang
Mei, Li
Xu, Jianxing
author_facet Zhu, Jiang
Yun, Jian
Wang, Kaixiang
Liu, Liangqing
Zheng, Jiangang
Mei, Li
Xu, Jianxing
author_sort Zhu, Jiang
collection PubMed
description OBJECTIVE: To evaluate the early chemotherapy response in patients with lung cancer using semiquantitative analysis of dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI). METHODS: Twenty-two patients with lung cancer treated with chemotherapy were subjected to DCE-MRI at two time points: before starting treatment and after one week of therapy. The image data were collected by DCE-MRI, and the semiquantitative parameters including positive enhancement integral (PEI), signal enhancement ratio (SER), maximum slope of increase (MSI), and time to peak (TTP) were calculated. After chemotherapy, the parameters and relevant variations between the responders and nonresponders were compared with Mann–Whitney U tests. Student's t-test for paired samples was used to evaluate the temporal changes between pre- and posttreatment images. RESULTS: The patients were categorized as 13 responders and 9 nonresponders based on the tumor response evaluation. After chemotherapy, the PEI, SER, and MSI were significantly increased in responders compared with the pretreatment values (P < 0.05), while no obvious decrease in TTP was observed (P > 0.05). However, 9 nonresponders showed no significant changes in PEI, SER, MSI, and TTP values, as compared with those of pretreatment (P > 0.05). Moreover, the increase of PEI was more dramatically in responders than in nonresponders (P < 0.05), but no significantly differences were observed in SER, MSI, and TTP (P > 0.05). CONCLUSION: Semiquantitative analysis of DCE-MRI could provide a reliable noninvasive method for assessing early chemotherapy response in lung cancer patients.
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spelling pubmed-93388492022-07-31 Assessment of Early Response to Lung Cancer Chemotherapy by Semiquantitative Analysis of Dynamic Contrast-Enhanced MRI Zhu, Jiang Yun, Jian Wang, Kaixiang Liu, Liangqing Zheng, Jiangang Mei, Li Xu, Jianxing Dis Markers Research Article OBJECTIVE: To evaluate the early chemotherapy response in patients with lung cancer using semiquantitative analysis of dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI). METHODS: Twenty-two patients with lung cancer treated with chemotherapy were subjected to DCE-MRI at two time points: before starting treatment and after one week of therapy. The image data were collected by DCE-MRI, and the semiquantitative parameters including positive enhancement integral (PEI), signal enhancement ratio (SER), maximum slope of increase (MSI), and time to peak (TTP) were calculated. After chemotherapy, the parameters and relevant variations between the responders and nonresponders were compared with Mann–Whitney U tests. Student's t-test for paired samples was used to evaluate the temporal changes between pre- and posttreatment images. RESULTS: The patients were categorized as 13 responders and 9 nonresponders based on the tumor response evaluation. After chemotherapy, the PEI, SER, and MSI were significantly increased in responders compared with the pretreatment values (P < 0.05), while no obvious decrease in TTP was observed (P > 0.05). However, 9 nonresponders showed no significant changes in PEI, SER, MSI, and TTP values, as compared with those of pretreatment (P > 0.05). Moreover, the increase of PEI was more dramatically in responders than in nonresponders (P < 0.05), but no significantly differences were observed in SER, MSI, and TTP (P > 0.05). CONCLUSION: Semiquantitative analysis of DCE-MRI could provide a reliable noninvasive method for assessing early chemotherapy response in lung cancer patients. Hindawi 2022-07-23 /pmc/articles/PMC9338849/ /pubmed/35915736 http://dx.doi.org/10.1155/2022/2669281 Text en Copyright © 2022 Jiang Zhu et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhu, Jiang
Yun, Jian
Wang, Kaixiang
Liu, Liangqing
Zheng, Jiangang
Mei, Li
Xu, Jianxing
Assessment of Early Response to Lung Cancer Chemotherapy by Semiquantitative Analysis of Dynamic Contrast-Enhanced MRI
title Assessment of Early Response to Lung Cancer Chemotherapy by Semiquantitative Analysis of Dynamic Contrast-Enhanced MRI
title_full Assessment of Early Response to Lung Cancer Chemotherapy by Semiquantitative Analysis of Dynamic Contrast-Enhanced MRI
title_fullStr Assessment of Early Response to Lung Cancer Chemotherapy by Semiquantitative Analysis of Dynamic Contrast-Enhanced MRI
title_full_unstemmed Assessment of Early Response to Lung Cancer Chemotherapy by Semiquantitative Analysis of Dynamic Contrast-Enhanced MRI
title_short Assessment of Early Response to Lung Cancer Chemotherapy by Semiquantitative Analysis of Dynamic Contrast-Enhanced MRI
title_sort assessment of early response to lung cancer chemotherapy by semiquantitative analysis of dynamic contrast-enhanced mri
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338849/
https://www.ncbi.nlm.nih.gov/pubmed/35915736
http://dx.doi.org/10.1155/2022/2669281
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