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Evaluation of transplacental transfer of mRNA vaccine products and functional antibodies during pregnancy and infancy
Studies are needed to evaluate the safety and effectiveness of mRNA SARS-CoV-2 vaccination during pregnancy, and the levels of protection provided to their newborns through placental transfer of antibodies. Here, we evaluate the transplacental transfer of mRNA vaccine products and functional anti-SA...
| Autores principales: | , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338928/ https://www.ncbi.nlm.nih.gov/pubmed/35908075 http://dx.doi.org/10.1038/s41467-022-32188-1 |
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| author | Prahl, Mary Golan, Yarden Cassidy, Arianna G. Matsui, Yusuke Li, Lin Alvarenga, Bonny Chen, Hao Jigmeddagva, Unurzul Lin, Christine Y. Gonzalez, Veronica J. Chidboy, Megan A. Warrier, Lakshmi Buarpung, Sirirak Murtha, Amy P. Flaherman, Valerie J. Greene, Warner C. Wu, Alan H. B. Lynch, Kara L. Rajan, Jayant Gaw, Stephanie L. |
| author_facet | Prahl, Mary Golan, Yarden Cassidy, Arianna G. Matsui, Yusuke Li, Lin Alvarenga, Bonny Chen, Hao Jigmeddagva, Unurzul Lin, Christine Y. Gonzalez, Veronica J. Chidboy, Megan A. Warrier, Lakshmi Buarpung, Sirirak Murtha, Amy P. Flaherman, Valerie J. Greene, Warner C. Wu, Alan H. B. Lynch, Kara L. Rajan, Jayant Gaw, Stephanie L. |
| author_sort | Prahl, Mary |
| collection | PubMed |
| description | Studies are needed to evaluate the safety and effectiveness of mRNA SARS-CoV-2 vaccination during pregnancy, and the levels of protection provided to their newborns through placental transfer of antibodies. Here, we evaluate the transplacental transfer of mRNA vaccine products and functional anti-SARS-CoV-2 antibodies during pregnancy and early infancy in a cohort of 20 individuals vaccinated during late pregnancy. We find no evidence of mRNA vaccine products in maternal blood, placenta tissue, or cord blood at delivery. However, we find time-dependent efficient transfer of IgG and neutralizing antibodies to the neonate that persists during early infancy. Additionally, using phage immunoprecipitation sequencing, we find a vaccine-specific signature of SARS-CoV-2 Spike protein epitope binding that is transplacentally transferred during pregnancy. Timing of vaccination during pregnancy is critical to ensure transplacental transfer of protective antibodies during early infancy. |
| format | Online Article Text |
| id | pubmed-9338928 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-93389282022-08-01 Evaluation of transplacental transfer of mRNA vaccine products and functional antibodies during pregnancy and infancy Prahl, Mary Golan, Yarden Cassidy, Arianna G. Matsui, Yusuke Li, Lin Alvarenga, Bonny Chen, Hao Jigmeddagva, Unurzul Lin, Christine Y. Gonzalez, Veronica J. Chidboy, Megan A. Warrier, Lakshmi Buarpung, Sirirak Murtha, Amy P. Flaherman, Valerie J. Greene, Warner C. Wu, Alan H. B. Lynch, Kara L. Rajan, Jayant Gaw, Stephanie L. Nat Commun Article Studies are needed to evaluate the safety and effectiveness of mRNA SARS-CoV-2 vaccination during pregnancy, and the levels of protection provided to their newborns through placental transfer of antibodies. Here, we evaluate the transplacental transfer of mRNA vaccine products and functional anti-SARS-CoV-2 antibodies during pregnancy and early infancy in a cohort of 20 individuals vaccinated during late pregnancy. We find no evidence of mRNA vaccine products in maternal blood, placenta tissue, or cord blood at delivery. However, we find time-dependent efficient transfer of IgG and neutralizing antibodies to the neonate that persists during early infancy. Additionally, using phage immunoprecipitation sequencing, we find a vaccine-specific signature of SARS-CoV-2 Spike protein epitope binding that is transplacentally transferred during pregnancy. Timing of vaccination during pregnancy is critical to ensure transplacental transfer of protective antibodies during early infancy. Nature Publishing Group UK 2022-07-30 /pmc/articles/PMC9338928/ /pubmed/35908075 http://dx.doi.org/10.1038/s41467-022-32188-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Article Prahl, Mary Golan, Yarden Cassidy, Arianna G. Matsui, Yusuke Li, Lin Alvarenga, Bonny Chen, Hao Jigmeddagva, Unurzul Lin, Christine Y. Gonzalez, Veronica J. Chidboy, Megan A. Warrier, Lakshmi Buarpung, Sirirak Murtha, Amy P. Flaherman, Valerie J. Greene, Warner C. Wu, Alan H. B. Lynch, Kara L. Rajan, Jayant Gaw, Stephanie L. Evaluation of transplacental transfer of mRNA vaccine products and functional antibodies during pregnancy and infancy |
| title | Evaluation of transplacental transfer of mRNA vaccine products and functional antibodies during pregnancy and infancy |
| title_full | Evaluation of transplacental transfer of mRNA vaccine products and functional antibodies during pregnancy and infancy |
| title_fullStr | Evaluation of transplacental transfer of mRNA vaccine products and functional antibodies during pregnancy and infancy |
| title_full_unstemmed | Evaluation of transplacental transfer of mRNA vaccine products and functional antibodies during pregnancy and infancy |
| title_short | Evaluation of transplacental transfer of mRNA vaccine products and functional antibodies during pregnancy and infancy |
| title_sort | evaluation of transplacental transfer of mrna vaccine products and functional antibodies during pregnancy and infancy |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338928/ https://www.ncbi.nlm.nih.gov/pubmed/35908075 http://dx.doi.org/10.1038/s41467-022-32188-1 |
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