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Exome sequencing revealed comparable frequencies of RNF43 and BRAF mutations in Middle Eastern colorectal cancer

Mutation-induced activation of Wnt-β Catenin signaling pathway is frequent in CRC. The E3 ubiquitin ligase, RNF43, has been reported to negatively regulate the Wnt signaling pathway and RNF43 mutations are frequently seen in CRC. However, its role in Middle Eastern CRC remains unclear. Therefore, we...

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Detalles Bibliográficos
Autores principales:	Siraj, Abdul Khalid, Bu, Rong, Masoodi, Tariq, Parvathareddy, Sandeep Kumar, Iqbal, Kaleem, Al-Haqawi, Wael, Al-Dossari, Hassan, Azam, Saud, Qadri, Zeeshan, Annaiyappanaidu, Padmanaban, Al-Dayel, Fouad, Al-Kuraya, Khawla Sami
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338933/ https://www.ncbi.nlm.nih.gov/pubmed/35907983 http://dx.doi.org/10.1038/s41598-022-17449-9

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