CDC-like kinase 4 deficiency contributes to pathological cardiac hypertrophy by modulating NEXN phosphorylation

Kinase-catalyzed phosphorylation plays a crucial role in pathological cardiac hypertrophy. Here, we show that CDC-like kinase 4 (CLK4) is a critical regulator of cardiomyocyte hypertrophy and heart failure. Knockdown of Clk4 leads to pathological cardiomyocyte hypertrophy, while overexpression of Cl...

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Detalles Bibliográficos
Autores principales: Huang, Jian, Wang, Luxin, Shen, Yunli, Zhang, Shengqi, Zhou, Yaqun, Du, Jimin, Ma, Xiue, Liu, Yi, Liang, Dandan, Shi, Dan, Ma, Honghui, Li, Li, Zhang, Qi, Chen, Yi-Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338968/
https://www.ncbi.nlm.nih.gov/pubmed/35907876
http://dx.doi.org/10.1038/s41467-022-31996-9

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