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Structural basis for assembly and disassembly of the IGF/IGFBP/ALS ternary complex
Insulin-like growth factors (IGFs) have pleiotropic roles in embryonic and postnatal growth and differentiation. Most serum IGFs are bound in a ternary complex with IGF-binding protein 3 (IGFBP3) and acid-labile subunit (ALS), extending the serum half-life of IGFs and regulating their availability....
Autores principales: | Kim, Hyojin, Fu, Yaoyao, Hong, Ho Jeong, Lee, Seong-Gyu, Lee, Dong Sun, Kim, Ho Min |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338993/ https://www.ncbi.nlm.nih.gov/pubmed/35907924 http://dx.doi.org/10.1038/s41467-022-32214-2 |
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