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Evidence accumulation occurs locally in the parietal cortex

Decision making often entails evidence accumulation, a process that is represented by neural activities in a network of multiple brain areas. Yet, it has not been identified where exactly the accumulation originates. We reason that a candidate brain area should both represent evidence accumulation a...

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Autores principales: Zhang, Zhewei, Yin, Chaoqun, Yang, Tianming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9339004/
https://www.ncbi.nlm.nih.gov/pubmed/35907908
http://dx.doi.org/10.1038/s41467-022-32210-6
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author Zhang, Zhewei
Yin, Chaoqun
Yang, Tianming
author_facet Zhang, Zhewei
Yin, Chaoqun
Yang, Tianming
author_sort Zhang, Zhewei
collection PubMed
description Decision making often entails evidence accumulation, a process that is represented by neural activities in a network of multiple brain areas. Yet, it has not been identified where exactly the accumulation originates. We reason that a candidate brain area should both represent evidence accumulation and information that is used to compute evidence. Therefore, we designed a two-stage probabilistic reasoning task in which the evidence for accumulation had to be first determined from sensory signals orthogonal to decisions. With a linear encoding model, we decomposed the responses of posterior parietal neurons to each stimulus into an early and a late component that represented two dissociable stages of decision making. The former reflected the transformation from sensory inputs to accumulable evidence, and the latter reflected the accumulation of evidence and the formation of decisions. The presence of both computational stages indicates that evidence accumulation signal in the parietal cortex is computed locally.
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spelling pubmed-93390042022-08-01 Evidence accumulation occurs locally in the parietal cortex Zhang, Zhewei Yin, Chaoqun Yang, Tianming Nat Commun Article Decision making often entails evidence accumulation, a process that is represented by neural activities in a network of multiple brain areas. Yet, it has not been identified where exactly the accumulation originates. We reason that a candidate brain area should both represent evidence accumulation and information that is used to compute evidence. Therefore, we designed a two-stage probabilistic reasoning task in which the evidence for accumulation had to be first determined from sensory signals orthogonal to decisions. With a linear encoding model, we decomposed the responses of posterior parietal neurons to each stimulus into an early and a late component that represented two dissociable stages of decision making. The former reflected the transformation from sensory inputs to accumulable evidence, and the latter reflected the accumulation of evidence and the formation of decisions. The presence of both computational stages indicates that evidence accumulation signal in the parietal cortex is computed locally. Nature Publishing Group UK 2022-07-30 /pmc/articles/PMC9339004/ /pubmed/35907908 http://dx.doi.org/10.1038/s41467-022-32210-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Zhang, Zhewei
Yin, Chaoqun
Yang, Tianming
Evidence accumulation occurs locally in the parietal cortex
title Evidence accumulation occurs locally in the parietal cortex
title_full Evidence accumulation occurs locally in the parietal cortex
title_fullStr Evidence accumulation occurs locally in the parietal cortex
title_full_unstemmed Evidence accumulation occurs locally in the parietal cortex
title_short Evidence accumulation occurs locally in the parietal cortex
title_sort evidence accumulation occurs locally in the parietal cortex
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9339004/
https://www.ncbi.nlm.nih.gov/pubmed/35907908
http://dx.doi.org/10.1038/s41467-022-32210-6
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