Characterization of serotonin as a candidate biomarker of severity and prognosis of COVID-19 using LC/MS analysis

The coronavirus disease 2019 (COVID-19) pandemic has been associated with high mortality worldwide. Owing to its complicated pathophysiology, diagnostic and prognostic biomarkers for effective patient management remain scarce. We analyzed kynurenine, tryptophan, and serotonin levels in the serum of...

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Autores principales: Saito, Kosuke, Ishikawa, Rika, Kitamura, Isao, Ogawa, Kumiko, Arakawa, Noriaki, Sun, Yuchen, Imai, Kazuo, Maeda, Takuya, Saito, Yoshiro, Hasegawa, Chihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society. 2022
Materias:
Full Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9339153/
https://www.ncbi.nlm.nih.gov/pubmed/36055751
http://dx.doi.org/10.1016/j.jphs.2022.06.005
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author Saito, Kosuke
Ishikawa, Rika
Kitamura, Isao
Ogawa, Kumiko
Arakawa, Noriaki
Sun, Yuchen
Imai, Kazuo
Maeda, Takuya
Saito, Yoshiro
Hasegawa, Chihiro
author_facet Saito, Kosuke
Ishikawa, Rika
Kitamura, Isao
Ogawa, Kumiko
Arakawa, Noriaki
Sun, Yuchen
Imai, Kazuo
Maeda, Takuya
Saito, Yoshiro
Hasegawa, Chihiro
author_sort Saito, Kosuke
collection PubMed
description The coronavirus disease 2019 (COVID-19) pandemic has been associated with high mortality worldwide. Owing to its complicated pathophysiology, diagnostic and prognostic biomarkers for effective patient management remain scarce. We analyzed kynurenine, tryptophan, and serotonin levels in the serum of patients with COVID-19 via liquid chromatography/mass spectrometry analysis. Serum serotonin levels were decreased in patients with more severe COVID-19, along with increased kynurenine and decreased tryptophan concentrations. Patients with moderate disease who subsequently worsened showed significantly lower serotonin concentrations compared with those who did not experience severe disease. Serum serotonin levels may represent a valuable biomarker for COVID-19 severity and prognosis.
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spelling pubmed-93391532022-08-01 Characterization of serotonin as a candidate biomarker of severity and prognosis of COVID-19 using LC/MS analysis Saito, Kosuke Ishikawa, Rika Kitamura, Isao Ogawa, Kumiko Arakawa, Noriaki Sun, Yuchen Imai, Kazuo Maeda, Takuya Saito, Yoshiro Hasegawa, Chihiro J Pharmacol Sci Full Paper The coronavirus disease 2019 (COVID-19) pandemic has been associated with high mortality worldwide. Owing to its complicated pathophysiology, diagnostic and prognostic biomarkers for effective patient management remain scarce. We analyzed kynurenine, tryptophan, and serotonin levels in the serum of patients with COVID-19 via liquid chromatography/mass spectrometry analysis. Serum serotonin levels were decreased in patients with more severe COVID-19, along with increased kynurenine and decreased tryptophan concentrations. Patients with moderate disease who subsequently worsened showed significantly lower serotonin concentrations compared with those who did not experience severe disease. Serum serotonin levels may represent a valuable biomarker for COVID-19 severity and prognosis. The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society. 2022-10 2022-07-31 /pmc/articles/PMC9339153/ /pubmed/36055751 http://dx.doi.org/10.1016/j.jphs.2022.06.005 Text en © 2022 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Full Paper
Saito, Kosuke
Ishikawa, Rika
Kitamura, Isao
Ogawa, Kumiko
Arakawa, Noriaki
Sun, Yuchen
Imai, Kazuo
Maeda, Takuya
Saito, Yoshiro
Hasegawa, Chihiro
Characterization of serotonin as a candidate biomarker of severity and prognosis of COVID-19 using LC/MS analysis
title Characterization of serotonin as a candidate biomarker of severity and prognosis of COVID-19 using LC/MS analysis
title_full Characterization of serotonin as a candidate biomarker of severity and prognosis of COVID-19 using LC/MS analysis
title_fullStr Characterization of serotonin as a candidate biomarker of severity and prognosis of COVID-19 using LC/MS analysis
title_full_unstemmed Characterization of serotonin as a candidate biomarker of severity and prognosis of COVID-19 using LC/MS analysis
title_short Characterization of serotonin as a candidate biomarker of severity and prognosis of COVID-19 using LC/MS analysis
title_sort characterization of serotonin as a candidate biomarker of severity and prognosis of covid-19 using lc/ms analysis
topic Full Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9339153/
https://www.ncbi.nlm.nih.gov/pubmed/36055751
http://dx.doi.org/10.1016/j.jphs.2022.06.005
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