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Fine-tuning acetyl-CoA carboxylase 1 activity through localization: functional genomics reveals a role for the lysine acetyltransferase NuA4 and sphingolipid metabolism in regulating Acc1 activity and localization

Acetyl-CoA Carboxylase 1 catalyzes the conversion of acetyl-CoA to malonyl-CoA, the committed step of de novo fatty acid synthesis. As a master regulator of lipid synthesis, acetyl-CoA carboxylase 1 has been proposed to be a therapeutic target for numerous metabolic diseases. We have shown that acet...

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Detalles Bibliográficos
Autores principales:	Pham, Trang, Walden, Elizabeth, Huard, Sylvain, Pezacki, John, Fullerton, Morgan D, Baetz, Kristin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Investigation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9339284/ https://www.ncbi.nlm.nih.gov/pubmed/35608294 http://dx.doi.org/10.1093/genetics/iyac086

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