Targeting PARP11 to avert immunosuppression and improve CAR T therapy in solid tumors

Evasion of anti-tumor immunity and resistance to therapies in solid tumors are aided by immune-suppressive tumor microenvironment (TME). We found that TME factors such as regulatory T cells and adenosine downregulated type I interferons (IFN1) receptor IFNAR1 on CD8(+) cytotoxic T lymphocytes (CTL)....

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Detalles Bibliográficos
Autores principales: Zhang, Hongru, Yu, Pengfei, Tomar, Vivek S., Chen, Xiangjie, Atherton, Matthew J., Lu, Zhen, Zhang, Hong-Guang, Li, Shifeng, Ortiz, Angelica, Gui, Jun, Leu, N. Adrian, Yan, Fangxue, Blanco, Andres, Meyer-Ficca, Mirella L., Meyer, Ralph G., Beiting, Daniel P., Li, Jinyang, Nunez-Cruz, Selene, O’Connor, Roddy S., Johnson, Lexus R., Minn, Andy J., George, Subin S., Koumenis, Constantinos, Diehl, J. Alan, Milone, Michael C., Zheng, Hui, Fuchs, Serge Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9339499/
https://www.ncbi.nlm.nih.gov/pubmed/35637402
http://dx.doi.org/10.1038/s43018-022-00383-0

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