From 2-Triethylammonium Ethyl Ether of 4-Stilbenol (MG624) to Selective Small-Molecule Antagonists of Human α9α10 Nicotinic Receptor by Modifications at the Ammonium Ethyl Residue

[Image: see text] Nicotinic acetylcholine receptors containing α9 subunits (α9*-nAChRs) are potential druggable targets arousing great interest for pain treatment alternative to opioids. Nonpeptidic small molecules selectively acting as α9*-nAChRs antagonists still remain an unattained goal. Here, t...

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Detalles Bibliográficos
Autores principales: Bavo, Francesco, Pallavicini, Marco, Pucci, Susanna, Appiani, Rebecca, Giraudo, Alessandro, Eaton, Brek, Lucero, Linda, Gotti, Cecilia, Moretti, Milena, Whiteaker, Paul, Bolchi, Cristiano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9339509/
https://www.ncbi.nlm.nih.gov/pubmed/35834819
http://dx.doi.org/10.1021/acs.jmedchem.2c00746

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