A Highly Selective GSK-3β Inhibitor CHIR99021 Promotes Osteogenesis by Activating Canonical and Autophagy-Mediated Wnt Signaling

The discovery and application of small molecules is one of the practical strategies of safe osteogenic drugs. The small molecule CHIR99021 (C91) is a highly specific, safe, and most effective GSK-3β Inhibitor. This study found that it efficiently activates the canonical Wnt signaling of bone marrow...

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Detalles Bibliográficos
Autores principales: Wang, Bo, Khan, Saima, Wang, Pengtao, Wang, Xiaofang, Liu, Yangxi, Chen, Jingjing, Tu, Xiaolin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9339598/
https://www.ncbi.nlm.nih.gov/pubmed/35923616
http://dx.doi.org/10.3389/fendo.2022.926622

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9339598/
https://www.ncbi.nlm.nih.gov/pubmed/35923616
http://dx.doi.org/10.3389/fendo.2022.926622

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