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A Highly Selective GSK-3β Inhibitor CHIR99021 Promotes Osteogenesis by Activating Canonical and Autophagy-Mediated Wnt Signaling

The discovery and application of small molecules is one of the practical strategies of safe osteogenic drugs. The small molecule CHIR99021 (C91) is a highly specific, safe, and most effective GSK-3β Inhibitor. This study found that it efficiently activates the canonical Wnt signaling of bone marrow...

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Detalles Bibliográficos
Autores principales:	Wang, Bo, Khan, Saima, Wang, Pengtao, Wang, Xiaofang, Liu, Yangxi, Chen, Jingjing, Tu, Xiaolin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Endocrinology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9339598/ https://www.ncbi.nlm.nih.gov/pubmed/35923616 http://dx.doi.org/10.3389/fendo.2022.926622

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