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Feasibility of a Novel Sparse Orthogonal Collimator–Based Preclinical Total Marrow Irradiation for Enhanced Dosimetric Conformality
Total marrow irradiation (TMI) has significantly improved radiation conditioning for hematopoietic cell transplantation in hematologic diseases by reducing conditioning-induced toxicities and improving survival outcomes in relapsed/refractory patients. Recently, preclinical three-dimensional image–g...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9339640/ https://www.ncbi.nlm.nih.gov/pubmed/35924145 http://dx.doi.org/10.3389/fonc.2022.941814 |
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author | Abdelhamid, Amr M. H. Jiang, Lu Zuro, Darren Liu, An Madabushi, Srideshikan Sargur Ghimire, Hemendra Wong, Jeffrey Y. C. Saldi, Simonetta Fulcheri, Christian Zucchetti, Claudio Pierini, Antonio Sheng, Ke Aristei, Cynthia Hui, Susanta K. |
author_facet | Abdelhamid, Amr M. H. Jiang, Lu Zuro, Darren Liu, An Madabushi, Srideshikan Sargur Ghimire, Hemendra Wong, Jeffrey Y. C. Saldi, Simonetta Fulcheri, Christian Zucchetti, Claudio Pierini, Antonio Sheng, Ke Aristei, Cynthia Hui, Susanta K. |
author_sort | Abdelhamid, Amr M. H. |
collection | PubMed |
description | Total marrow irradiation (TMI) has significantly improved radiation conditioning for hematopoietic cell transplantation in hematologic diseases by reducing conditioning-induced toxicities and improving survival outcomes in relapsed/refractory patients. Recently, preclinical three-dimensional image–guided TMI has been developed to enhance mechanistic understanding of the role of TMI and to support the development of experimental therapeutics. However, a dosimetric comparison between preclinical and clinical TMI reveals that the preclinical TMI treatment lacks the ability to reduce the dose to some of the vital organs that are very close to the skeletal system and thus limits the ability to evaluate radiobiological relevance. To overcome this limit, we introduce a novel Sparse Orthogonal Collimator (SOC)–based TMI and evaluate its ability to enhance dosimetric conformality. The SOC-TMI–based dose modulation technique significantly improves TMI treatment planning by reducing radiation exposures to critical organs that are close to the skeletal system that leads to reducing the gap between clinical and preclinical TMI. |
format | Online Article Text |
id | pubmed-9339640 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93396402022-08-02 Feasibility of a Novel Sparse Orthogonal Collimator–Based Preclinical Total Marrow Irradiation for Enhanced Dosimetric Conformality Abdelhamid, Amr M. H. Jiang, Lu Zuro, Darren Liu, An Madabushi, Srideshikan Sargur Ghimire, Hemendra Wong, Jeffrey Y. C. Saldi, Simonetta Fulcheri, Christian Zucchetti, Claudio Pierini, Antonio Sheng, Ke Aristei, Cynthia Hui, Susanta K. Front Oncol Oncology Total marrow irradiation (TMI) has significantly improved radiation conditioning for hematopoietic cell transplantation in hematologic diseases by reducing conditioning-induced toxicities and improving survival outcomes in relapsed/refractory patients. Recently, preclinical three-dimensional image–guided TMI has been developed to enhance mechanistic understanding of the role of TMI and to support the development of experimental therapeutics. However, a dosimetric comparison between preclinical and clinical TMI reveals that the preclinical TMI treatment lacks the ability to reduce the dose to some of the vital organs that are very close to the skeletal system and thus limits the ability to evaluate radiobiological relevance. To overcome this limit, we introduce a novel Sparse Orthogonal Collimator (SOC)–based TMI and evaluate its ability to enhance dosimetric conformality. The SOC-TMI–based dose modulation technique significantly improves TMI treatment planning by reducing radiation exposures to critical organs that are close to the skeletal system that leads to reducing the gap between clinical and preclinical TMI. Frontiers Media S.A. 2022-07-18 /pmc/articles/PMC9339640/ /pubmed/35924145 http://dx.doi.org/10.3389/fonc.2022.941814 Text en Copyright © 2022 Abdelhamid, Jiang, Zuro, Liu, Madabushi, Ghimire, Wong, Saldi, Fulcheri, Zucchetti, Pierini, Sheng, Aristei and Hui https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Abdelhamid, Amr M. H. Jiang, Lu Zuro, Darren Liu, An Madabushi, Srideshikan Sargur Ghimire, Hemendra Wong, Jeffrey Y. C. Saldi, Simonetta Fulcheri, Christian Zucchetti, Claudio Pierini, Antonio Sheng, Ke Aristei, Cynthia Hui, Susanta K. Feasibility of a Novel Sparse Orthogonal Collimator–Based Preclinical Total Marrow Irradiation for Enhanced Dosimetric Conformality |
title | Feasibility of a Novel Sparse Orthogonal Collimator–Based Preclinical Total Marrow Irradiation for Enhanced Dosimetric Conformality |
title_full | Feasibility of a Novel Sparse Orthogonal Collimator–Based Preclinical Total Marrow Irradiation for Enhanced Dosimetric Conformality |
title_fullStr | Feasibility of a Novel Sparse Orthogonal Collimator–Based Preclinical Total Marrow Irradiation for Enhanced Dosimetric Conformality |
title_full_unstemmed | Feasibility of a Novel Sparse Orthogonal Collimator–Based Preclinical Total Marrow Irradiation for Enhanced Dosimetric Conformality |
title_short | Feasibility of a Novel Sparse Orthogonal Collimator–Based Preclinical Total Marrow Irradiation for Enhanced Dosimetric Conformality |
title_sort | feasibility of a novel sparse orthogonal collimator–based preclinical total marrow irradiation for enhanced dosimetric conformality |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9339640/ https://www.ncbi.nlm.nih.gov/pubmed/35924145 http://dx.doi.org/10.3389/fonc.2022.941814 |
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