Cargando…

Feasibility of a Novel Sparse Orthogonal Collimator–Based Preclinical Total Marrow Irradiation for Enhanced Dosimetric Conformality

Total marrow irradiation (TMI) has significantly improved radiation conditioning for hematopoietic cell transplantation in hematologic diseases by reducing conditioning-induced toxicities and improving survival outcomes in relapsed/refractory patients. Recently, preclinical three-dimensional image–g...

Descripción completa

Detalles Bibliográficos
Autores principales: Abdelhamid, Amr M. H., Jiang, Lu, Zuro, Darren, Liu, An, Madabushi, Srideshikan Sargur, Ghimire, Hemendra, Wong, Jeffrey Y. C., Saldi, Simonetta, Fulcheri, Christian, Zucchetti, Claudio, Pierini, Antonio, Sheng, Ke, Aristei, Cynthia, Hui, Susanta K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9339640/
https://www.ncbi.nlm.nih.gov/pubmed/35924145
http://dx.doi.org/10.3389/fonc.2022.941814
_version_ 1784760212314390528
author Abdelhamid, Amr M. H.
Jiang, Lu
Zuro, Darren
Liu, An
Madabushi, Srideshikan Sargur
Ghimire, Hemendra
Wong, Jeffrey Y. C.
Saldi, Simonetta
Fulcheri, Christian
Zucchetti, Claudio
Pierini, Antonio
Sheng, Ke
Aristei, Cynthia
Hui, Susanta K.
author_facet Abdelhamid, Amr M. H.
Jiang, Lu
Zuro, Darren
Liu, An
Madabushi, Srideshikan Sargur
Ghimire, Hemendra
Wong, Jeffrey Y. C.
Saldi, Simonetta
Fulcheri, Christian
Zucchetti, Claudio
Pierini, Antonio
Sheng, Ke
Aristei, Cynthia
Hui, Susanta K.
author_sort Abdelhamid, Amr M. H.
collection PubMed
description Total marrow irradiation (TMI) has significantly improved radiation conditioning for hematopoietic cell transplantation in hematologic diseases by reducing conditioning-induced toxicities and improving survival outcomes in relapsed/refractory patients. Recently, preclinical three-dimensional image–guided TMI has been developed to enhance mechanistic understanding of the role of TMI and to support the development of experimental therapeutics. However, a dosimetric comparison between preclinical and clinical TMI reveals that the preclinical TMI treatment lacks the ability to reduce the dose to some of the vital organs that are very close to the skeletal system and thus limits the ability to evaluate radiobiological relevance. To overcome this limit, we introduce a novel Sparse Orthogonal Collimator (SOC)–based TMI and evaluate its ability to enhance dosimetric conformality. The SOC-TMI–based dose modulation technique significantly improves TMI treatment planning by reducing radiation exposures to critical organs that are close to the skeletal system that leads to reducing the gap between clinical and preclinical TMI.
format Online
Article
Text
id pubmed-9339640
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-93396402022-08-02 Feasibility of a Novel Sparse Orthogonal Collimator–Based Preclinical Total Marrow Irradiation for Enhanced Dosimetric Conformality Abdelhamid, Amr M. H. Jiang, Lu Zuro, Darren Liu, An Madabushi, Srideshikan Sargur Ghimire, Hemendra Wong, Jeffrey Y. C. Saldi, Simonetta Fulcheri, Christian Zucchetti, Claudio Pierini, Antonio Sheng, Ke Aristei, Cynthia Hui, Susanta K. Front Oncol Oncology Total marrow irradiation (TMI) has significantly improved radiation conditioning for hematopoietic cell transplantation in hematologic diseases by reducing conditioning-induced toxicities and improving survival outcomes in relapsed/refractory patients. Recently, preclinical three-dimensional image–guided TMI has been developed to enhance mechanistic understanding of the role of TMI and to support the development of experimental therapeutics. However, a dosimetric comparison between preclinical and clinical TMI reveals that the preclinical TMI treatment lacks the ability to reduce the dose to some of the vital organs that are very close to the skeletal system and thus limits the ability to evaluate radiobiological relevance. To overcome this limit, we introduce a novel Sparse Orthogonal Collimator (SOC)–based TMI and evaluate its ability to enhance dosimetric conformality. The SOC-TMI–based dose modulation technique significantly improves TMI treatment planning by reducing radiation exposures to critical organs that are close to the skeletal system that leads to reducing the gap between clinical and preclinical TMI. Frontiers Media S.A. 2022-07-18 /pmc/articles/PMC9339640/ /pubmed/35924145 http://dx.doi.org/10.3389/fonc.2022.941814 Text en Copyright © 2022 Abdelhamid, Jiang, Zuro, Liu, Madabushi, Ghimire, Wong, Saldi, Fulcheri, Zucchetti, Pierini, Sheng, Aristei and Hui https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Abdelhamid, Amr M. H.
Jiang, Lu
Zuro, Darren
Liu, An
Madabushi, Srideshikan Sargur
Ghimire, Hemendra
Wong, Jeffrey Y. C.
Saldi, Simonetta
Fulcheri, Christian
Zucchetti, Claudio
Pierini, Antonio
Sheng, Ke
Aristei, Cynthia
Hui, Susanta K.
Feasibility of a Novel Sparse Orthogonal Collimator–Based Preclinical Total Marrow Irradiation for Enhanced Dosimetric Conformality
title Feasibility of a Novel Sparse Orthogonal Collimator–Based Preclinical Total Marrow Irradiation for Enhanced Dosimetric Conformality
title_full Feasibility of a Novel Sparse Orthogonal Collimator–Based Preclinical Total Marrow Irradiation for Enhanced Dosimetric Conformality
title_fullStr Feasibility of a Novel Sparse Orthogonal Collimator–Based Preclinical Total Marrow Irradiation for Enhanced Dosimetric Conformality
title_full_unstemmed Feasibility of a Novel Sparse Orthogonal Collimator–Based Preclinical Total Marrow Irradiation for Enhanced Dosimetric Conformality
title_short Feasibility of a Novel Sparse Orthogonal Collimator–Based Preclinical Total Marrow Irradiation for Enhanced Dosimetric Conformality
title_sort feasibility of a novel sparse orthogonal collimator–based preclinical total marrow irradiation for enhanced dosimetric conformality
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9339640/
https://www.ncbi.nlm.nih.gov/pubmed/35924145
http://dx.doi.org/10.3389/fonc.2022.941814
work_keys_str_mv AT abdelhamidamrmh feasibilityofanovelsparseorthogonalcollimatorbasedpreclinicaltotalmarrowirradiationforenhanceddosimetricconformality
AT jianglu feasibilityofanovelsparseorthogonalcollimatorbasedpreclinicaltotalmarrowirradiationforenhanceddosimetricconformality
AT zurodarren feasibilityofanovelsparseorthogonalcollimatorbasedpreclinicaltotalmarrowirradiationforenhanceddosimetricconformality
AT liuan feasibilityofanovelsparseorthogonalcollimatorbasedpreclinicaltotalmarrowirradiationforenhanceddosimetricconformality
AT madabushisrideshikansargur feasibilityofanovelsparseorthogonalcollimatorbasedpreclinicaltotalmarrowirradiationforenhanceddosimetricconformality
AT ghimirehemendra feasibilityofanovelsparseorthogonalcollimatorbasedpreclinicaltotalmarrowirradiationforenhanceddosimetricconformality
AT wongjeffreyyc feasibilityofanovelsparseorthogonalcollimatorbasedpreclinicaltotalmarrowirradiationforenhanceddosimetricconformality
AT saldisimonetta feasibilityofanovelsparseorthogonalcollimatorbasedpreclinicaltotalmarrowirradiationforenhanceddosimetricconformality
AT fulcherichristian feasibilityofanovelsparseorthogonalcollimatorbasedpreclinicaltotalmarrowirradiationforenhanceddosimetricconformality
AT zucchetticlaudio feasibilityofanovelsparseorthogonalcollimatorbasedpreclinicaltotalmarrowirradiationforenhanceddosimetricconformality
AT pieriniantonio feasibilityofanovelsparseorthogonalcollimatorbasedpreclinicaltotalmarrowirradiationforenhanceddosimetricconformality
AT shengke feasibilityofanovelsparseorthogonalcollimatorbasedpreclinicaltotalmarrowirradiationforenhanceddosimetricconformality
AT aristeicynthia feasibilityofanovelsparseorthogonalcollimatorbasedpreclinicaltotalmarrowirradiationforenhanceddosimetricconformality
AT huisusantak feasibilityofanovelsparseorthogonalcollimatorbasedpreclinicaltotalmarrowirradiationforenhanceddosimetricconformality