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Distribution of pediatric keratoconus by different age and gender groups

PURPOSE: To evaluate the distribution of pediatric keratoconus patients and the disease severity based on different age and gender groups in China. MATERIALS AND METHODS: A total of 446 keratoconus eyes in 266 pediatric patients from January 2019 to January 2022 were included in the cross-sectional...

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Autores principales: Yang, Kaili, Gu, Yuwei, Xu, Liyan, Fan, Qi, Zhu, Meng, Wang, Qing, Yin, Shanshan, Zhang, Bo, Pang, Chenjiu, Ren, Shengwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9339668/
https://www.ncbi.nlm.nih.gov/pubmed/35923788
http://dx.doi.org/10.3389/fped.2022.937246
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author Yang, Kaili
Gu, Yuwei
Xu, Liyan
Fan, Qi
Zhu, Meng
Wang, Qing
Yin, Shanshan
Zhang, Bo
Pang, Chenjiu
Ren, Shengwei
author_facet Yang, Kaili
Gu, Yuwei
Xu, Liyan
Fan, Qi
Zhu, Meng
Wang, Qing
Yin, Shanshan
Zhang, Bo
Pang, Chenjiu
Ren, Shengwei
author_sort Yang, Kaili
collection PubMed
description PURPOSE: To evaluate the distribution of pediatric keratoconus patients and the disease severity based on different age and gender groups in China. MATERIALS AND METHODS: A total of 446 keratoconus eyes in 266 pediatric patients from January 2019 to January 2022 were included in the cross-sectional study. The clinical findings and severity of keratoconus were recorded and Kruskal–Wallis test, chi-squared test, and Cochran-Mantel-Haenszel (CMH) test were used to compare the parameters between different gender and age groups. RESULTS: The male/female ratio was 353/93 (3.8:1), and the median age was 16 years (range: 6–17 years). Male patients were statistically younger than female patients (P = 0.041). The male/female ratio decreased with age (P for trend = 0.011). The distribution of the topographic keratoconus classification (TKC) stage was significantly different between gender and age groups (all P < 0.05). Male patients had a higher ratio of advanced keratoconus eyes (TKC ≥ 3) than female patients (P < 0.001), and CMH analysis indicated that being a male was a risk factor for advanced keratoconus after controlling for age (odds ratio: 2.581, P < 0.001). CONCLUSION: Male keratoconus patients were younger, with a higher ratio of advanced keratoconus than female patients in the Chinese pediatric patients evaluated. Multicenter studies with larger sample sizes are necessary in the future.
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spelling pubmed-93396682022-08-02 Distribution of pediatric keratoconus by different age and gender groups Yang, Kaili Gu, Yuwei Xu, Liyan Fan, Qi Zhu, Meng Wang, Qing Yin, Shanshan Zhang, Bo Pang, Chenjiu Ren, Shengwei Front Pediatr Pediatrics PURPOSE: To evaluate the distribution of pediatric keratoconus patients and the disease severity based on different age and gender groups in China. MATERIALS AND METHODS: A total of 446 keratoconus eyes in 266 pediatric patients from January 2019 to January 2022 were included in the cross-sectional study. The clinical findings and severity of keratoconus were recorded and Kruskal–Wallis test, chi-squared test, and Cochran-Mantel-Haenszel (CMH) test were used to compare the parameters between different gender and age groups. RESULTS: The male/female ratio was 353/93 (3.8:1), and the median age was 16 years (range: 6–17 years). Male patients were statistically younger than female patients (P = 0.041). The male/female ratio decreased with age (P for trend = 0.011). The distribution of the topographic keratoconus classification (TKC) stage was significantly different between gender and age groups (all P < 0.05). Male patients had a higher ratio of advanced keratoconus eyes (TKC ≥ 3) than female patients (P < 0.001), and CMH analysis indicated that being a male was a risk factor for advanced keratoconus after controlling for age (odds ratio: 2.581, P < 0.001). CONCLUSION: Male keratoconus patients were younger, with a higher ratio of advanced keratoconus than female patients in the Chinese pediatric patients evaluated. Multicenter studies with larger sample sizes are necessary in the future. Frontiers Media S.A. 2022-07-18 /pmc/articles/PMC9339668/ /pubmed/35923788 http://dx.doi.org/10.3389/fped.2022.937246 Text en Copyright © 2022 Yang, Gu, Xu, Fan, Zhu, Wang, Yin, Zhang, Pang and Ren. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Yang, Kaili
Gu, Yuwei
Xu, Liyan
Fan, Qi
Zhu, Meng
Wang, Qing
Yin, Shanshan
Zhang, Bo
Pang, Chenjiu
Ren, Shengwei
Distribution of pediatric keratoconus by different age and gender groups
title Distribution of pediatric keratoconus by different age and gender groups
title_full Distribution of pediatric keratoconus by different age and gender groups
title_fullStr Distribution of pediatric keratoconus by different age and gender groups
title_full_unstemmed Distribution of pediatric keratoconus by different age and gender groups
title_short Distribution of pediatric keratoconus by different age and gender groups
title_sort distribution of pediatric keratoconus by different age and gender groups
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9339668/
https://www.ncbi.nlm.nih.gov/pubmed/35923788
http://dx.doi.org/10.3389/fped.2022.937246
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