Use of off-label compounded oral sildenafil in the management of persistent pulmonary hypertension of the newborn: A case report

We report a case of a newborn with persistent pulmonary hypertension (PPHN) due to meconium aspiration syndrome with associated lung collapse. Echocardiogram revealed features of persistent pulmonary hypertension. He was treated with compounded oral sildenafil. Oral sildenafil has proven to be effec...

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Autores principales: Daniyan, Olapeju, Ezeanosike, Obumneme, Obu, Dorathy, Ujunwa, Fortune
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tabriz University of Medical Sciences 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9339734/
https://www.ncbi.nlm.nih.gov/pubmed/35935381
http://dx.doi.org/10.34172/jcvtr.2022.03
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author Daniyan, Olapeju
Ezeanosike, Obumneme
Obu, Dorathy
Ujunwa, Fortune
author_facet Daniyan, Olapeju
Ezeanosike, Obumneme
Obu, Dorathy
Ujunwa, Fortune
author_sort Daniyan, Olapeju
collection PubMed
description We report a case of a newborn with persistent pulmonary hypertension (PPHN) due to meconium aspiration syndrome with associated lung collapse. Echocardiogram revealed features of persistent pulmonary hypertension. He was treated with compounded oral sildenafil. Oral sildenafil has proven to be effective and safe in the management of PPHN in neonates with persistent pulmonary hypertension. Therefore, in situations where inhaled nitric oxide is not available it may be used as an alternative therapy in PPHN. Further randomized controlled studies are needed to determine its efficacy and pharmacokinetics.
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spelling pubmed-93397342022-08-04 Use of off-label compounded oral sildenafil in the management of persistent pulmonary hypertension of the newborn: A case report Daniyan, Olapeju Ezeanosike, Obumneme Obu, Dorathy Ujunwa, Fortune J Cardiovasc Thorac Res Case Report We report a case of a newborn with persistent pulmonary hypertension (PPHN) due to meconium aspiration syndrome with associated lung collapse. Echocardiogram revealed features of persistent pulmonary hypertension. He was treated with compounded oral sildenafil. Oral sildenafil has proven to be effective and safe in the management of PPHN in neonates with persistent pulmonary hypertension. Therefore, in situations where inhaled nitric oxide is not available it may be used as an alternative therapy in PPHN. Further randomized controlled studies are needed to determine its efficacy and pharmacokinetics. Tabriz University of Medical Sciences 2022 2022-03-07 /pmc/articles/PMC9339734/ /pubmed/35935381 http://dx.doi.org/10.34172/jcvtr.2022.03 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Daniyan, Olapeju
Ezeanosike, Obumneme
Obu, Dorathy
Ujunwa, Fortune
Use of off-label compounded oral sildenafil in the management of persistent pulmonary hypertension of the newborn: A case report
title Use of off-label compounded oral sildenafil in the management of persistent pulmonary hypertension of the newborn: A case report
title_full Use of off-label compounded oral sildenafil in the management of persistent pulmonary hypertension of the newborn: A case report
title_fullStr Use of off-label compounded oral sildenafil in the management of persistent pulmonary hypertension of the newborn: A case report
title_full_unstemmed Use of off-label compounded oral sildenafil in the management of persistent pulmonary hypertension of the newborn: A case report
title_short Use of off-label compounded oral sildenafil in the management of persistent pulmonary hypertension of the newborn: A case report
title_sort use of off-label compounded oral sildenafil in the management of persistent pulmonary hypertension of the newborn: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9339734/
https://www.ncbi.nlm.nih.gov/pubmed/35935381
http://dx.doi.org/10.34172/jcvtr.2022.03
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