Prevention and treatment of natural products from Traditional Chinese Medicine in depression: Potential targets and mechanisms of action

The molecular pathology involved in the development of depression is complex. Many signaling pathways and transcription factors have been demonstrated to display crucial roles in the process of depression occurrence and development. The multi-components and multi-targets of Traditional Chinese Medic...

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Detalles Bibliográficos
Autores principales: He, Ming-Chao, Feng, Rui, Wang, Jing, Xia, Shi-Hui, Wang, Yong-Jun, Zhang, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9339961/
https://www.ncbi.nlm.nih.gov/pubmed/35923544
http://dx.doi.org/10.3389/fnagi.2022.950143
Descripción
Sumario:The molecular pathology involved in the development of depression is complex. Many signaling pathways and transcription factors have been demonstrated to display crucial roles in the process of depression occurrence and development. The multi-components and multi-targets of Traditional Chinese Medicine (TCM) are uniquely advantageous in the prevention and treatment of chronic diseases. This review summarizes the pharmacological regulations of natural products from TCM in the prevention and treatment of depression from the aspects of transcription factors (CREB, NF-κB, Nrf2) and molecular signaling pathways (BDNF-TrkB, MAPK, GSK-3β, TLR-4).

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