Prevention and treatment of natural products from Traditional Chinese Medicine in depression: Potential targets and mechanisms of action

The molecular pathology involved in the development of depression is complex. Many signaling pathways and transcription factors have been demonstrated to display crucial roles in the process of depression occurrence and development. The multi-components and multi-targets of Traditional Chinese Medic...

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Autores principales: He, Ming-Chao, Feng, Rui, Wang, Jing, Xia, Shi-Hui, Wang, Yong-Jun, Zhang, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9339961/
https://www.ncbi.nlm.nih.gov/pubmed/35923544
http://dx.doi.org/10.3389/fnagi.2022.950143
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author He, Ming-Chao
Feng, Rui
Wang, Jing
Xia, Shi-Hui
Wang, Yong-Jun
Zhang, Yan
author_facet He, Ming-Chao
Feng, Rui
Wang, Jing
Xia, Shi-Hui
Wang, Yong-Jun
Zhang, Yan
author_sort He, Ming-Chao
collection PubMed
description The molecular pathology involved in the development of depression is complex. Many signaling pathways and transcription factors have been demonstrated to display crucial roles in the process of depression occurrence and development. The multi-components and multi-targets of Traditional Chinese Medicine (TCM) are uniquely advantageous in the prevention and treatment of chronic diseases. This review summarizes the pharmacological regulations of natural products from TCM in the prevention and treatment of depression from the aspects of transcription factors (CREB, NF-κB, Nrf2) and molecular signaling pathways (BDNF-TrkB, MAPK, GSK-3β, TLR-4).
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spelling pubmed-93399612022-08-02 Prevention and treatment of natural products from Traditional Chinese Medicine in depression: Potential targets and mechanisms of action He, Ming-Chao Feng, Rui Wang, Jing Xia, Shi-Hui Wang, Yong-Jun Zhang, Yan Front Aging Neurosci Neuroscience The molecular pathology involved in the development of depression is complex. Many signaling pathways and transcription factors have been demonstrated to display crucial roles in the process of depression occurrence and development. The multi-components and multi-targets of Traditional Chinese Medicine (TCM) are uniquely advantageous in the prevention and treatment of chronic diseases. This review summarizes the pharmacological regulations of natural products from TCM in the prevention and treatment of depression from the aspects of transcription factors (CREB, NF-κB, Nrf2) and molecular signaling pathways (BDNF-TrkB, MAPK, GSK-3β, TLR-4). Frontiers Media S.A. 2022-07-18 /pmc/articles/PMC9339961/ /pubmed/35923544 http://dx.doi.org/10.3389/fnagi.2022.950143 Text en Copyright © 2022 He, Feng, Wang, Xia, Wang and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
He, Ming-Chao
Feng, Rui
Wang, Jing
Xia, Shi-Hui
Wang, Yong-Jun
Zhang, Yan
Prevention and treatment of natural products from Traditional Chinese Medicine in depression: Potential targets and mechanisms of action
title Prevention and treatment of natural products from Traditional Chinese Medicine in depression: Potential targets and mechanisms of action
title_full Prevention and treatment of natural products from Traditional Chinese Medicine in depression: Potential targets and mechanisms of action
title_fullStr Prevention and treatment of natural products from Traditional Chinese Medicine in depression: Potential targets and mechanisms of action
title_full_unstemmed Prevention and treatment of natural products from Traditional Chinese Medicine in depression: Potential targets and mechanisms of action
title_short Prevention and treatment of natural products from Traditional Chinese Medicine in depression: Potential targets and mechanisms of action
title_sort prevention and treatment of natural products from traditional chinese medicine in depression: potential targets and mechanisms of action
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9339961/
https://www.ncbi.nlm.nih.gov/pubmed/35923544
http://dx.doi.org/10.3389/fnagi.2022.950143
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