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Aptamers targeting SARS-COV-2: a promising tool to fight against COVID-19

SARS-CoV-2, the causative agent of COVID-19, remains among the main causes of global mortality. Although antigen/antibody-based immunoassays and neutralizing antibodies targeting SARS-CoV-2 have been successfully developed over the past 2 years, they are often inefficient and unreliable for emerging...

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Detalles Bibliográficos
Autores principales: Zhang, Yang, Juhas, Mario, Kwok, Chun Kit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9340053/
https://www.ncbi.nlm.nih.gov/pubmed/35995601
http://dx.doi.org/10.1016/j.tibtech.2022.07.012
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author Zhang, Yang
Juhas, Mario
Kwok, Chun Kit
author_facet Zhang, Yang
Juhas, Mario
Kwok, Chun Kit
author_sort Zhang, Yang
collection PubMed
description SARS-CoV-2, the causative agent of COVID-19, remains among the main causes of global mortality. Although antigen/antibody-based immunoassays and neutralizing antibodies targeting SARS-CoV-2 have been successfully developed over the past 2 years, they are often inefficient and unreliable for emerging SARS-CoV-2 variants. Novel approaches against SARS-CoV-2 and its variants are therefore urgently needed. Aptamers have been developed for the detection and inhibition of several different viruses such as HIV, influenza viruses, Middle East respiratory syndrome coronavirus (MERS-CoV), and SARS-CoV. Aptamers targeting SARS-CoV-2 represent a promising tool in the fight against COVID-19, which is of paramount importance for the current and any future pandemics. This review presents recent advances and future trends in the development of aptamer-based approaches for SARS-CoV-2 diagnosis and treatment.
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spelling pubmed-93400532022-08-01 Aptamers targeting SARS-COV-2: a promising tool to fight against COVID-19 Zhang, Yang Juhas, Mario Kwok, Chun Kit Trends Biotechnol Review SARS-CoV-2, the causative agent of COVID-19, remains among the main causes of global mortality. Although antigen/antibody-based immunoassays and neutralizing antibodies targeting SARS-CoV-2 have been successfully developed over the past 2 years, they are often inefficient and unreliable for emerging SARS-CoV-2 variants. Novel approaches against SARS-CoV-2 and its variants are therefore urgently needed. Aptamers have been developed for the detection and inhibition of several different viruses such as HIV, influenza viruses, Middle East respiratory syndrome coronavirus (MERS-CoV), and SARS-CoV. Aptamers targeting SARS-CoV-2 represent a promising tool in the fight against COVID-19, which is of paramount importance for the current and any future pandemics. This review presents recent advances and future trends in the development of aptamer-based approaches for SARS-CoV-2 diagnosis and treatment. Elsevier Ltd. 2023-04 2022-08-01 /pmc/articles/PMC9340053/ /pubmed/35995601 http://dx.doi.org/10.1016/j.tibtech.2022.07.012 Text en © 2022 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Zhang, Yang
Juhas, Mario
Kwok, Chun Kit
Aptamers targeting SARS-COV-2: a promising tool to fight against COVID-19
title Aptamers targeting SARS-COV-2: a promising tool to fight against COVID-19
title_full Aptamers targeting SARS-COV-2: a promising tool to fight against COVID-19
title_fullStr Aptamers targeting SARS-COV-2: a promising tool to fight against COVID-19
title_full_unstemmed Aptamers targeting SARS-COV-2: a promising tool to fight against COVID-19
title_short Aptamers targeting SARS-COV-2: a promising tool to fight against COVID-19
title_sort aptamers targeting sars-cov-2: a promising tool to fight against covid-19
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9340053/
https://www.ncbi.nlm.nih.gov/pubmed/35995601
http://dx.doi.org/10.1016/j.tibtech.2022.07.012
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