Functional role of miR-34a in diabetes and frailty

Emerging evidence has shown that microRNAs (miRNAs) play critical role in the pathogenesis of several disorders. In the present minireview, we focus our attention on the functional role of a specific miRNA, namely miR-34a, in the pathophysiology of frailty and diabetes mellitus. Based on the current...

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Autores principales: Mone, Pasquale, de Donato, Antonio, Varzideh, Fahimeh, Kansakar, Urna, Jankauskas, Stanislovas S., Pansini, Antonella, Santulli, Gaetano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Aging
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9340262/
https://www.ncbi.nlm.nih.gov/pubmed/35923683
http://dx.doi.org/10.3389/fragi.2022.949924
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author Mone, Pasquale
de Donato, Antonio
Varzideh, Fahimeh
Kansakar, Urna
Jankauskas, Stanislovas S.
Pansini, Antonella
Santulli, Gaetano
author_facet Mone, Pasquale
de Donato, Antonio
Varzideh, Fahimeh
Kansakar, Urna
Jankauskas, Stanislovas S.
Pansini, Antonella
Santulli, Gaetano
author_sort Mone, Pasquale
collection PubMed
description Emerging evidence has shown that microRNAs (miRNAs) play critical role in the pathogenesis of several disorders. In the present minireview, we focus our attention on the functional role of a specific miRNA, namely miR-34a, in the pathophysiology of frailty and diabetes mellitus. Based on the current literature, we speculate that this miRNA may serve as a potential biomarker of frailty in diabetic older adults. Additionally, its actions on oxidative stress might represent a druggable target to obtain new potentials treatments.
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spelling pubmed-93402622022-08-02 Functional role of miR-34a in diabetes and frailty Mone, Pasquale de Donato, Antonio Varzideh, Fahimeh Kansakar, Urna Jankauskas, Stanislovas S. Pansini, Antonella Santulli, Gaetano Front Aging Aging Emerging evidence has shown that microRNAs (miRNAs) play critical role in the pathogenesis of several disorders. In the present minireview, we focus our attention on the functional role of a specific miRNA, namely miR-34a, in the pathophysiology of frailty and diabetes mellitus. Based on the current literature, we speculate that this miRNA may serve as a potential biomarker of frailty in diabetic older adults. Additionally, its actions on oxidative stress might represent a druggable target to obtain new potentials treatments. Frontiers Media S.A. 2022-07-18 /pmc/articles/PMC9340262/ /pubmed/35923683 http://dx.doi.org/10.3389/fragi.2022.949924 Text en Copyright © 2022 Mone, de Donato, Varzideh, Kansakar, Jankauskas, Pansini and Santulli. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Aging
Mone, Pasquale
de Donato, Antonio
Varzideh, Fahimeh
Kansakar, Urna
Jankauskas, Stanislovas S.
Pansini, Antonella
Santulli, Gaetano
Functional role of miR-34a in diabetes and frailty
title Functional role of miR-34a in diabetes and frailty
title_full Functional role of miR-34a in diabetes and frailty
title_fullStr Functional role of miR-34a in diabetes and frailty
title_full_unstemmed Functional role of miR-34a in diabetes and frailty
title_short Functional role of miR-34a in diabetes and frailty
title_sort functional role of mir-34a in diabetes and frailty
topic Aging
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9340262/
https://www.ncbi.nlm.nih.gov/pubmed/35923683
http://dx.doi.org/10.3389/fragi.2022.949924
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