Cargando…

Drug‐resistant epilepsy: Drug target hypothesis and beyond the receptors

Epilepsy is a chronic neurological disorder that affects more than 50 million people worldwide. Despite a recent introduction of antiseizure drugs for the treatment of epileptic seizures, one‐third of these patients suffer from drug‐resistant epilepsy (DRE). The therapeutic target hypothesis is a ci...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fonseca‐Barriendos, Daniel, Frías‐Soria, Christian Lizette, Pérez‐Pérez, Daniel, Gómez‐López, Rosenda, Borroto Escuela, Dasiel O., Rocha, Luisa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Critical Reviews
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9340308/ https://www.ncbi.nlm.nih.gov/pubmed/34542940 http://dx.doi.org/10.1002/epi4.12539

Ejemplares similares

Is cannabidiol a drug acting on unconventional targets to control drug‐resistant epilepsy?
por: Rocha, Luisa, et al.
Publicado: (2020)

Drug‐resistant epilepsy and the hypothesis of intrinsic severity: What about the high‐frequency oscillations?
por: Santana‐Gomez, Cesar E., et al.
Publicado: (2021)

Introduction to the special issue “Redesigning the hypotheses for drug‐resistant epilepsy”
por: Rocha, Luisa
Publicado: (2022)

Volume transmission and receptor-receptor interactions in heteroreceptor complexes: understanding the role of new concepts for brain communication
por: Fuxe, Kjell, et al.
Publicado: (2016)

Can Allosteric Receptor-Protein Interactions in Receptor Complexes Be a Molecular Mechanism Involved in Cancer Immune Therapy?
por: Borroto-Escuela, Dasiel O., et al.
Publicado: (2019)

Adenosine heteroreceptor complexes in the basal ganglia are implicated in Parkinson’s disease and its treatment
por: Borroto-Escuela, Dasiel O., et al.
Publicado: (2019)

Oligomeric Receptor Complexes and Their Allosteric Receptor-Receptor Interactions in the Plasma Membrane Represent a New Biological Principle for Integration of Signals in the CNS
por: Borroto-Escuela, Dasiel O., et al.
Publicado: (2019)

On the G Protein-Coupled Receptor Neuromodulation of the Claustrum
por: Borroto-Escuela, Dasiel O., et al.
Publicado: (2019)

The integrative role of G protein-coupled receptor heterocomplexes in Parkinson’s disease
por: Borroto-Escuela, Dasiel O., et al.
Publicado: (2022)

Factors not considered in the study of drug‐resistant epilepsy: Drug‐resistant epilepsy: Assessment of neuroinflammation
por: Campos‐Bedolla, Patricia, et al.
Publicado: (2022)

Transporter hypothesis in pharmacoresistant epilepsies. Is it at the central or peripheral level?
por: Czornyj, Liliana, et al.
Publicado: (2021)

The gut microbiome in drug‐resistant epilepsy
por: Chatzikonstantinou, Simela, et al.
Publicado: (2021)

Molecular Integration in Adenosine Heteroreceptor Complexes Through Allosteric and De-Phosphorylation (STEP) Mechanisms and its Role in Brain Disease
por: Borroto-Escuela, Dasiel O., et al.
Publicado: (2022)

Transcranial Focal Electrical Stimulation Modifies Biogenic Amines’ Alterations Induced by 6-Hydroxydopamine in Rat Brain
por: Santana-Gómez, Cesar Emmanuel, et al.
Publicado: (2021)

Drug resistance in idiopathic generalized epilepsies: Evidence and concepts
por: Gesche, Joanna, et al.
Publicado: (2022)

Potential of caveolae in the therapy of cardiovascular and neurological diseases
por: Navarro, Gemma, et al.
Publicado: (2014)

Drug‐resistant epilepsy and mortality—Why and when do neuromodulation and epilepsy surgery reduce overall mortality
por: Rheims, Sylvain, et al.
Publicado: (2022)

IL1R2, CCR2, and CXCR4 May Form Heteroreceptor Complexes with NMDAR and D2R: Relevance for Schizophrenia
por: Borroto-Escuela, Dasiel O., et al.
Publicado: (2017)

Not all that glitters is gold: A guide to the critical interpretation of drug trials in epilepsy
por: Perucca, Emilio, et al.
Publicado: (2016)

Factors not considered in the study of drug‐resistant epilepsy: Psychiatric comorbidities, age, and gender
por: Medel‐Matus, Jesús Servando, et al.
Publicado: (2022)

On the role of A(2A) and D(2) receptors in control of cocaine and food-seeking behaviors in rats
por: Wydra, Karolina, et al.
Publicado: (2014)

Not all that glitters is gold: A guide to critical appraisal of animal drug trials in epilepsy
por: Galanopoulou, Aristea S., et al.
Publicado: (2016)

The role of efflux transporters and metabolizing enzymes in brain and peripheral organs to explain drug‐resistant epilepsy
por: Vázquez, Marta, et al.
Publicado: (2021)

Evidence for the existence of facilitatory interactions between the dopamine D2 receptor and the oxytocin receptor in the amygdala of the rat. Relevance for anxiolytic actions
por: Hernández-Mondragón, Juan Carlos, et al.
Publicado: (2023)

Evidence for the existence of dopamine D2R and Sigma 1 allosteric receptor-receptor interaction in the rat brain: role in brain plasticity and cocaine action
por: Pinton, Luca, et al.
Publicado: (2015)

Understanding the Role of Adenosine A2AR Heteroreceptor Complexes in Neurodegeneration and Neuroinflammation
por: Borroto-Escuela, Dasiel O., et al.
Publicado: (2018)

Heterodimerization of Mu Opioid Receptor Protomer with Dopamine D(2) Receptor Modulates Agonist-Induced Internalization of Mu Opioid Receptor
por: Vasudevan, Lakshmi, et al.
Publicado: (2019)

OOPS, I CLOTTED AGAIN! A CASE OF RECURRENT VTE AND POTENTIAL DRUG-DRUG INTERACTIONS IN TREATMENT OF COVID-19
por: SANTONE, DANIEL, et al.
Publicado: (2021)

Adenosine A(2A)Receptors in Substance Use Disorders: A Focus on Cocaine
por: Wydra, Karolina, et al.
Publicado: (2020)

Differential allosteric modulation within dopamine D(2)R - neurotensin NTS1R and D(2)R - serotonin 5-HT(2A)R receptor complexes gives bias to intracellular calcium signalling
por: Plach, Michael, et al.
Publicado: (2019)

Desipramine restores the alterations in circadian entrainment induced by prenatal exposure to glucocorticoids
por: Spulber, Stefan, et al.
Publicado: (2019)

Biodegradable nanoparticles for the treatment of epilepsy: From current advances to future challenges
por: Bonilla, Lorena, et al.
Publicado: (2021)

The initial impact of the SARS‐CoV‐2 pandemic on epilepsy research
por: Volkers, Nancy, et al.
Publicado: (2021)

OSU-6162, a Sigma1R Ligand in Low Doses, Can Further Increase the Effects of Cocaine Self-Administration on Accumbal D2R Heteroreceptor Complexes
por: Borroto-Escuela, Dasiel O., et al.
Publicado: (2019)

A2AR Transmembrane 2 Peptide Administration Disrupts the A2AR-A2AR Homoreceptor but Not the A2AR-D2R Heteroreceptor Complex: Lack of Actions on Rodent Cocaine Self-Administration
por: Borroto-Escuela, Dasiel O., et al.
Publicado: (2019)

Disruption of A2AR-D2R Heteroreceptor Complexes After A2AR Transmembrane 5 Peptide Administration Enhances Cocaine Self-Administration in Rats
por: Borroto-Escuela, Dasiel O., et al.
Publicado: (2018)

Multiple Adenosine-Dopamine (A2A-D2 Like) Heteroreceptor Complexes in the Brain and Their Role in Schizophrenia
por: Borroto-Escuela, Dasiel O., et al.
Publicado: (2020)

Relative timing of mitochondrial endosymbiosis and the “pre‐mitochondrial symbioses” hypothesis
por: Gabaldón, Toni
Publicado: (2018)

The oxytocin receptor represents a key hub in the GPCR heteroreceptor network: potential relevance for brain and behavior
por: Borroto-Escuela, Dasiel O., et al.
Publicado: (2022)

Adenosine and Kynurenic Acid Interactions: Possible Relevance for Schizophrenia Treatment?
por: Beggiato, Sarah, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_o8l6056kujmg511f9qk0f1q3r7