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Small Interfering RNA in Colorectal Cancer Liver Metastasis Therapy
Colorectal cancer (CRC) is associated with numerous genetic disorders and cellular abnormalities, and liver metastasis is a common health concern in patients with CRC. Exploring newer and more efficient therapies to block liver metastasis is pivotal for prolonging patient survival. Therefore, small...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9340422/ https://www.ncbi.nlm.nih.gov/pubmed/35899305 http://dx.doi.org/10.1177/15330338221103318 |
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author | Xie, Junlin Wang, Shubin |
author_facet | Xie, Junlin Wang, Shubin |
author_sort | Xie, Junlin |
collection | PubMed |
description | Colorectal cancer (CRC) is associated with numerous genetic disorders and cellular abnormalities, and liver metastasis is a common health concern in patients with CRC. Exploring newer and more efficient therapies to block liver metastasis is pivotal for prolonging patient survival. Therefore, small interfering RNAs (siRNAs) are expected to be remarkable tools capable of regulating gene expression by participating in a process called RNA interference (RNAi). RNAi is a biological process among eukaryotes wherein specific messenger RNA (mRNA) molecules are destroyed and gene expression is inhibited. This technology is a promising therapeutic agent in the treatment of CRC liver metastasis (CRLM). Nevertheless, crucial problems in siRNA therapeutics, including inherent poor serum stability and nonspecific uptake into biological systems, must be recognized. For this reason, delivery systems are being developed in an attempt to solve these problems. Here, we discuss the utility of siRNA therapy for the treatment of CRCLM by targeting the major metastasis-related signaling pathways. siRNA therapy has the potential to be one of the most effective methods for CRLM treatment in the future. |
format | Online Article Text |
id | pubmed-9340422 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-93404222022-08-02 Small Interfering RNA in Colorectal Cancer Liver Metastasis Therapy Xie, Junlin Wang, Shubin Technol Cancer Res Treat Review Colorectal cancer (CRC) is associated with numerous genetic disorders and cellular abnormalities, and liver metastasis is a common health concern in patients with CRC. Exploring newer and more efficient therapies to block liver metastasis is pivotal for prolonging patient survival. Therefore, small interfering RNAs (siRNAs) are expected to be remarkable tools capable of regulating gene expression by participating in a process called RNA interference (RNAi). RNAi is a biological process among eukaryotes wherein specific messenger RNA (mRNA) molecules are destroyed and gene expression is inhibited. This technology is a promising therapeutic agent in the treatment of CRC liver metastasis (CRLM). Nevertheless, crucial problems in siRNA therapeutics, including inherent poor serum stability and nonspecific uptake into biological systems, must be recognized. For this reason, delivery systems are being developed in an attempt to solve these problems. Here, we discuss the utility of siRNA therapy for the treatment of CRCLM by targeting the major metastasis-related signaling pathways. siRNA therapy has the potential to be one of the most effective methods for CRLM treatment in the future. SAGE Publications 2022-07-27 /pmc/articles/PMC9340422/ /pubmed/35899305 http://dx.doi.org/10.1177/15330338221103318 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Review Xie, Junlin Wang, Shubin Small Interfering RNA in Colorectal Cancer Liver Metastasis Therapy |
title | Small Interfering RNA in Colorectal Cancer Liver Metastasis
Therapy |
title_full | Small Interfering RNA in Colorectal Cancer Liver Metastasis
Therapy |
title_fullStr | Small Interfering RNA in Colorectal Cancer Liver Metastasis
Therapy |
title_full_unstemmed | Small Interfering RNA in Colorectal Cancer Liver Metastasis
Therapy |
title_short | Small Interfering RNA in Colorectal Cancer Liver Metastasis
Therapy |
title_sort | small interfering rna in colorectal cancer liver metastasis
therapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9340422/ https://www.ncbi.nlm.nih.gov/pubmed/35899305 http://dx.doi.org/10.1177/15330338221103318 |
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