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Small Interfering RNA in Colorectal Cancer Liver Metastasis Therapy

Colorectal cancer (CRC) is associated with numerous genetic disorders and cellular abnormalities, and liver metastasis is a common health concern in patients with CRC. Exploring newer and more efficient therapies to block liver metastasis is pivotal for prolonging patient survival. Therefore, small...

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Detalles Bibliográficos
Autores principales: Xie, Junlin, Wang, Shubin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9340422/
https://www.ncbi.nlm.nih.gov/pubmed/35899305
http://dx.doi.org/10.1177/15330338221103318
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author Xie, Junlin
Wang, Shubin
author_facet Xie, Junlin
Wang, Shubin
author_sort Xie, Junlin
collection PubMed
description Colorectal cancer (CRC) is associated with numerous genetic disorders and cellular abnormalities, and liver metastasis is a common health concern in patients with CRC. Exploring newer and more efficient therapies to block liver metastasis is pivotal for prolonging patient survival. Therefore, small interfering RNAs (siRNAs) are expected to be remarkable tools capable of regulating gene expression by participating in a process called RNA interference (RNAi). RNAi is a biological process among eukaryotes wherein specific messenger RNA (mRNA) molecules are destroyed and gene expression is inhibited. This technology is a promising therapeutic agent in the treatment of CRC liver metastasis (CRLM). Nevertheless, crucial problems in siRNA therapeutics, including inherent poor serum stability and nonspecific uptake into biological systems, must be recognized. For this reason, delivery systems are being developed in an attempt to solve these problems. Here, we discuss the utility of siRNA therapy for the treatment of CRCLM by targeting the major metastasis-related signaling pathways. siRNA therapy has the potential to be one of the most effective methods for CRLM treatment in the future.
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spelling pubmed-93404222022-08-02 Small Interfering RNA in Colorectal Cancer Liver Metastasis Therapy Xie, Junlin Wang, Shubin Technol Cancer Res Treat Review Colorectal cancer (CRC) is associated with numerous genetic disorders and cellular abnormalities, and liver metastasis is a common health concern in patients with CRC. Exploring newer and more efficient therapies to block liver metastasis is pivotal for prolonging patient survival. Therefore, small interfering RNAs (siRNAs) are expected to be remarkable tools capable of regulating gene expression by participating in a process called RNA interference (RNAi). RNAi is a biological process among eukaryotes wherein specific messenger RNA (mRNA) molecules are destroyed and gene expression is inhibited. This technology is a promising therapeutic agent in the treatment of CRC liver metastasis (CRLM). Nevertheless, crucial problems in siRNA therapeutics, including inherent poor serum stability and nonspecific uptake into biological systems, must be recognized. For this reason, delivery systems are being developed in an attempt to solve these problems. Here, we discuss the utility of siRNA therapy for the treatment of CRCLM by targeting the major metastasis-related signaling pathways. siRNA therapy has the potential to be one of the most effective methods for CRLM treatment in the future. SAGE Publications 2022-07-27 /pmc/articles/PMC9340422/ /pubmed/35899305 http://dx.doi.org/10.1177/15330338221103318 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Xie, Junlin
Wang, Shubin
Small Interfering RNA in Colorectal Cancer Liver Metastasis Therapy
title Small Interfering RNA in Colorectal Cancer Liver Metastasis Therapy
title_full Small Interfering RNA in Colorectal Cancer Liver Metastasis Therapy
title_fullStr Small Interfering RNA in Colorectal Cancer Liver Metastasis Therapy
title_full_unstemmed Small Interfering RNA in Colorectal Cancer Liver Metastasis Therapy
title_short Small Interfering RNA in Colorectal Cancer Liver Metastasis Therapy
title_sort small interfering rna in colorectal cancer liver metastasis therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9340422/
https://www.ncbi.nlm.nih.gov/pubmed/35899305
http://dx.doi.org/10.1177/15330338221103318
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