Cargando…
Carcinogenesis induced by space radiation: A systematic review
The carcinogenic risk from space radiation has always been a health risk issue of great concern during space exploration. In recent years, a large number of cellular and animal experiments have demonstrated that space radiation, composed of high-energy protons and heavy ions, has shown obvious carci...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Neoplasia Press
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9340504/ https://www.ncbi.nlm.nih.gov/pubmed/35908380 http://dx.doi.org/10.1016/j.neo.2022.100828 |
_version_ | 1784760419654565888 |
---|---|
author | Guo, Zi Zhou, Guangming Hu, Wentao |
author_facet | Guo, Zi Zhou, Guangming Hu, Wentao |
author_sort | Guo, Zi |
collection | PubMed |
description | The carcinogenic risk from space radiation has always been a health risk issue of great concern during space exploration. In recent years, a large number of cellular and animal experiments have demonstrated that space radiation, composed of high-energy protons and heavy ions, has shown obvious carcinogenicity. However, different from radiation on Earth, space radiation has the characteristics of high energy and low dose rate. It is rich in high-atom-number and high-energy particles and, as it is combined with other space environmental factors such as microgravity and a weak magnetic field, the study of its carcinogenic effects and mechanisms of action is difficult, which leads to great uncertainty in its carcinogenic risk assessment. Here, we review the latest progress in understanding the effects and mechanisms of action related to cell transformation and carcinogenesis induced by space radiation in recent years and summarize the prediction models of cancer risk caused by space radiation and the methods to reduce the uncertainty of prediction to provide reference for the research and risk assessment of space radiation. |
format | Online Article Text |
id | pubmed-9340504 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Neoplasia Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-93405042022-08-09 Carcinogenesis induced by space radiation: A systematic review Guo, Zi Zhou, Guangming Hu, Wentao Neoplasia Review Article The carcinogenic risk from space radiation has always been a health risk issue of great concern during space exploration. In recent years, a large number of cellular and animal experiments have demonstrated that space radiation, composed of high-energy protons and heavy ions, has shown obvious carcinogenicity. However, different from radiation on Earth, space radiation has the characteristics of high energy and low dose rate. It is rich in high-atom-number and high-energy particles and, as it is combined with other space environmental factors such as microgravity and a weak magnetic field, the study of its carcinogenic effects and mechanisms of action is difficult, which leads to great uncertainty in its carcinogenic risk assessment. Here, we review the latest progress in understanding the effects and mechanisms of action related to cell transformation and carcinogenesis induced by space radiation in recent years and summarize the prediction models of cancer risk caused by space radiation and the methods to reduce the uncertainty of prediction to provide reference for the research and risk assessment of space radiation. Neoplasia Press 2022-07-28 /pmc/articles/PMC9340504/ /pubmed/35908380 http://dx.doi.org/10.1016/j.neo.2022.100828 Text en © 2022 The Authors. Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article Guo, Zi Zhou, Guangming Hu, Wentao Carcinogenesis induced by space radiation: A systematic review |
title | Carcinogenesis induced by space radiation: A systematic review |
title_full | Carcinogenesis induced by space radiation: A systematic review |
title_fullStr | Carcinogenesis induced by space radiation: A systematic review |
title_full_unstemmed | Carcinogenesis induced by space radiation: A systematic review |
title_short | Carcinogenesis induced by space radiation: A systematic review |
title_sort | carcinogenesis induced by space radiation: a systematic review |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9340504/ https://www.ncbi.nlm.nih.gov/pubmed/35908380 http://dx.doi.org/10.1016/j.neo.2022.100828 |
work_keys_str_mv | AT guozi carcinogenesisinducedbyspaceradiationasystematicreview AT zhouguangming carcinogenesisinducedbyspaceradiationasystematicreview AT huwentao carcinogenesisinducedbyspaceradiationasystematicreview |