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Effects of JAK1-Preferential Inhibitor Filgotinib on Circulating Biomarkers and Whole Blood Genes/Pathways of Patients With Moderately to Severely Active Crohn’s Disease

BACKGROUND: Pro-inflammatory cytokines are dysregulated in Crohn’s disease (CD) and could serve as surrogate markers to improve diagnostic and therapeutic approaches, potentially addressing an unmet need. We profiled circulating biomarkers and whole blood transcriptional pathway activity to identify...

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Detalles Bibliográficos
Autores principales:	Roblin, Xavier, Serone, Adrian, Yoon, Oh Kyu, Zhuo,, Luting, Grant, Ethan, Woo, Jacky, Liu, Jinfeng, Galien, René, D’Haens, Geert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Clinical Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9340524/ https://www.ncbi.nlm.nih.gov/pubmed/34741617 http://dx.doi.org/10.1093/ibd/izab253

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