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A comprehensive multi-omics analysis reveals molecular features associated with cancer via RNA cross-talks in the Notch signaling pathway
The Notch signaling has an important role in multiple cellular processes and is related to carcinogenic process. To understand the potential molecular features of the crucial Notch pathway, a comprehensive multi-omics analysis is performed to explore its contributions in cancer, mainly including ana...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Research Network of Computational and Structural Biotechnology
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9340535/ https://www.ncbi.nlm.nih.gov/pubmed/35950189 http://dx.doi.org/10.1016/j.csbj.2022.07.036 |
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author | Guo, Li Li, Sunjing Yan, Xiaoqiang Shen, Lulu Xia, Daoliang Xiong, Yiqi Dou, Yuyang Mi, Lan Ren, Yujie Xiang, Yangyang Ren, Dekang Wang, Jun Liang, Tingming |
author_facet | Guo, Li Li, Sunjing Yan, Xiaoqiang Shen, Lulu Xia, Daoliang Xiong, Yiqi Dou, Yuyang Mi, Lan Ren, Yujie Xiang, Yangyang Ren, Dekang Wang, Jun Liang, Tingming |
author_sort | Guo, Li |
collection | PubMed |
description | The Notch signaling has an important role in multiple cellular processes and is related to carcinogenic process. To understand the potential molecular features of the crucial Notch pathway, a comprehensive multi-omics analysis is performed to explore its contributions in cancer, mainly including analysis of somatic mutation landscape, pan-cancer expression, ncRNA regulation and potential prognostic power. The screened 22 Notch core genes are relative stable in DNA variation. Dynamic expression patterns are associated with the Notch activity, which are mainly regulated by multiple ncRNAs via interactions of ncRNA:mRNA and ceRNA networks. The Notch pathway shows a potential prognostic ability through integrating multi-omics features as well as their targets, and it is correlated with immune infiltration and maybe available drug targets, implying the potential role in individualized treatment. Collectively, all of these findings contribute to exploring crucial role of the key pathway in cancer pathophysiology and gaining mechanistic insights into cross-talks among RNAs and biological pathways, which indicates the possible application of the well-conserved Notch signaling pathway in precision medicine. |
format | Online Article Text |
id | pubmed-9340535 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Research Network of Computational and Structural Biotechnology |
record_format | MEDLINE/PubMed |
spelling | pubmed-93405352022-08-09 A comprehensive multi-omics analysis reveals molecular features associated with cancer via RNA cross-talks in the Notch signaling pathway Guo, Li Li, Sunjing Yan, Xiaoqiang Shen, Lulu Xia, Daoliang Xiong, Yiqi Dou, Yuyang Mi, Lan Ren, Yujie Xiang, Yangyang Ren, Dekang Wang, Jun Liang, Tingming Comput Struct Biotechnol J Research Article The Notch signaling has an important role in multiple cellular processes and is related to carcinogenic process. To understand the potential molecular features of the crucial Notch pathway, a comprehensive multi-omics analysis is performed to explore its contributions in cancer, mainly including analysis of somatic mutation landscape, pan-cancer expression, ncRNA regulation and potential prognostic power. The screened 22 Notch core genes are relative stable in DNA variation. Dynamic expression patterns are associated with the Notch activity, which are mainly regulated by multiple ncRNAs via interactions of ncRNA:mRNA and ceRNA networks. The Notch pathway shows a potential prognostic ability through integrating multi-omics features as well as their targets, and it is correlated with immune infiltration and maybe available drug targets, implying the potential role in individualized treatment. Collectively, all of these findings contribute to exploring crucial role of the key pathway in cancer pathophysiology and gaining mechanistic insights into cross-talks among RNAs and biological pathways, which indicates the possible application of the well-conserved Notch signaling pathway in precision medicine. Research Network of Computational and Structural Biotechnology 2022-07-26 /pmc/articles/PMC9340535/ /pubmed/35950189 http://dx.doi.org/10.1016/j.csbj.2022.07.036 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Research Article Guo, Li Li, Sunjing Yan, Xiaoqiang Shen, Lulu Xia, Daoliang Xiong, Yiqi Dou, Yuyang Mi, Lan Ren, Yujie Xiang, Yangyang Ren, Dekang Wang, Jun Liang, Tingming A comprehensive multi-omics analysis reveals molecular features associated with cancer via RNA cross-talks in the Notch signaling pathway |
title | A comprehensive multi-omics analysis reveals molecular features associated with cancer via RNA cross-talks in the Notch signaling pathway |
title_full | A comprehensive multi-omics analysis reveals molecular features associated with cancer via RNA cross-talks in the Notch signaling pathway |
title_fullStr | A comprehensive multi-omics analysis reveals molecular features associated with cancer via RNA cross-talks in the Notch signaling pathway |
title_full_unstemmed | A comprehensive multi-omics analysis reveals molecular features associated with cancer via RNA cross-talks in the Notch signaling pathway |
title_short | A comprehensive multi-omics analysis reveals molecular features associated with cancer via RNA cross-talks in the Notch signaling pathway |
title_sort | comprehensive multi-omics analysis reveals molecular features associated with cancer via rna cross-talks in the notch signaling pathway |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9340535/ https://www.ncbi.nlm.nih.gov/pubmed/35950189 http://dx.doi.org/10.1016/j.csbj.2022.07.036 |
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