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Combination of BMI1 and MAPK/ERK inhibitors is effective in medulloblastoma

BACKGROUND: Epigenetic changes play a key role in the pathogenesis of medulloblastoma (MB), the most common malignant pediatric brain tumor. METHODS: We explore the therapeutic potential of BMI1 and MAPK/ERK inhibition in BMI1(High);CHD7(Low) MB cells and in a preclinical xenograft model. RESULTS: W...

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Detalles Bibliográficos
Autores principales:	Badodi, Sara, Pomella, Nicola, Lim, Yau Mun, Brandner, Sebastian, Morrison, Gillian, Pollard, Steven M, Zhang, Xinyu, Zabet, Nicolae Radu, Marino, Silvia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Basic and Translational Investigations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9340634/ https://www.ncbi.nlm.nih.gov/pubmed/35213723 http://dx.doi.org/10.1093/neuonc/noac052

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