Discovery and Optimization of a Synthetic Class of Nectin-4-Targeted CD137 Agonists for Immuno-oncology

[Image: see text] CD137 (4-1BB) is a co-stimulatory receptor on immune cells and Nectin-4 is a cell adhesion molecule that is overexpressed in multiple tumor types. Using a series of poly(ethylene glycol) (PEG)-based linkers, synthetic bicyclic peptides targeting CD137 were conjugated to Bicycles ta...

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Detalles Bibliográficos
Autores principales: Upadhyaya, Punit, Kristensson, Julia, Lahdenranta, Johanna, Repash, Elizabeth, Ma, Jun, Kublin, Jessica, Mudd, Gemma E., Luus, Lia, Jeffrey, Phil, Hurov, Kristen, McDonnell, Kevin, Keen, Nicholas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9340768/
https://www.ncbi.nlm.nih.gov/pubmed/35819182
http://dx.doi.org/10.1021/acs.jmedchem.2c00505

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