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Identification of Human Alanine–Glyoxylate Aminotransferase Ligands as Pharmacological Chaperones for Variants Associated with Primary Hyperoxaluria Type 1

[Image: see text] Primary hyperoxaluria type I (PH1) is a rare kidney disease due to the deficit of alanine:glyoxylate aminotransferase (AGT), a pyridoxal-5′-phosphate-dependent enzyme responsible for liver glyoxylate detoxification, which in turn prevents oxalate formation and precipitation as kidn...

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Detalles Bibliográficos
Autores principales:	Grottelli, Silvia, Annunziato, Giannamaria, Pampalone, Gioena, Pieroni, Marco, Dindo, Mirco, Ferlenghi, Francesca, Costantino, Gabriele, Cellini, Barbara
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9340776/ https://www.ncbi.nlm.nih.gov/pubmed/35830169 http://dx.doi.org/10.1021/acs.jmedchem.2c00142

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